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Sildenafil’s impact on male infertility: what has changed in 20 years?
International Journal of Impotence Research ( IF 2.6 ) Pub Date : 2019-03-05 , DOI: 10.1038/s41443-018-0067-x
Nickolas D. Scherzer , Tan V. Le , Wayne J. G. Hellstrom

Sildenafil has had a dramatic influence on the field of sexual medicine over the past 20 years. Not only have phosphodiesterase-5 (PDE5) inhibitors improved the treatment of erectile dysfunction (ED), they have indirectly contributed to the treatment of male factor infertility. A review of the literature between 1998 - 2018 was performed using PubMed with regards to sildenafil and male infertility. Numerous studies have demonstrated sildenafil’s safety and efficacy for treating ED. Sildenafil does not alter semen parameters, and, in fact, may positively affect semen parameters. Sildenafil is helpful for treating ED caused by the psychological stress of infertility treatments. Sildenafil has improved the treatment of ED and may have a benefit on semen parameters. This has aided in the management of male factor infertility, and has contributed to hundreds of thousands of pregnancies that would have been more difficult, as it was before its advent.



中文翻译:

西地那非对男性不育的影响:20年以来发生了什么变化?

西地那非在过去20年中对性医学领域产生了巨大影响。磷酸二酯酶5(PDE5)抑制剂不仅改善了勃起功能障碍(ED)的治疗,而且还间接地促进了男性因素不育的治疗。使用PubMed对西地那非和男性不育症进行了1998-2018年文献回顾。大量研究表明西地那非治疗ED的安全性和有效性。西地那非不会改变精液参数,实际上可能会对精液参数产生积极影响。西地那非有助于治疗由不育症治疗引起的心理压力引起的ED。西地那非改善了ED的治疗,可能对精液参数有好处。这有助于管理男性因素不孕症,

更新日期:2019-07-05
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