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Depression in inflammatory bowel disease: risk factor, prodrome or extraintestinal manifestation?
Gut ( IF 24.5 ) Pub Date : 2019-02-26 , DOI: 10.1136/gutjnl-2019-318444
Calum D Moulton 1 , Christine Norton 2 , Nick Powell 3 , Zahra Mohamedali 4 , Christopher W P Hopkins 5
Affiliation  

We read with interest Frolkis and colleagues’ recent study, in which depression was associated with increased risk of incident IBD in a large primary care database.1 While treatment of depression in IBD has been suggested to improve IBD outcomes,2 this study goes further, suggesting that assertive pharmacological treatment of depression could reduce the incidence of IBD altogether. Despite the study’s manifest strengths, we wish to draw the authors’ attention to an important limitation of its current design that tempers its conclusions. Temporality between exposure and outcome is a key test of causality.3 This is challenging in the context of depression and IBD because their symptoms …

中文翻译:

炎症性肠病抑郁症:危险因素、前驱症状还是肠外表现?

我们饶有兴趣地阅读了 Frolkis 及其同事最近的研究,其中在大型初级保健数据库中,抑郁症与 IBD 事件风险增加有关。1 虽然有人建议对 IBD 中的抑郁症进行治疗,以改善 IBD 的结果2,但这项研究更进一步,表明对抑郁症采取果断的药物治疗可以完全降低 IBD 的发病率。尽管该研究具有明显的优势,但我们希望让作者注意其当前设计的一个重要限制,该限制会影响其结论。暴露和结果之间的时间性是因果关系的关键测试。3 这在抑郁症和 IBD 的背景下具有挑战性,因为它们的症状……
更新日期:2019-02-26
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