This review describes an adult rat model of status epilepticus (SE) induced by diisopropyl fluorophosphate (DFP), and the beneficial outcomes of transient inhibition of the prostaglandin-E2 receptor EP2 with a small molecule antagonist, delayed by 2-4 h after SE onset. Administration of six doses of the selective EP2 antagonist TG6-10-1 over a 2-3 day period accelerates functional recovery, attenuates hippocampal neurodegeneration, neuroinflammation, gliosis and blood-brain barrier leakage, and prevents long-term cognitive deficits without blocking SE itself or altering acute seizure characteristics. This work has provided important information regarding organophosphate-induced seizure related pathologies in adults and revealed the effectiveness of delayed EP2 inhibition to combat these pathologies.

中文翻译：

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有机磷诱导的癫痫持续状态的大鼠模型和 EP2 受体抑制的有益作用。

本综述描述了由氟磷酸二异丙酯 (DFP) 诱导的成年大鼠癫痫持续状态 (SE) 模型，以及使用小分子拮抗剂瞬时抑制前列腺素 E2 受体 EP2 的有益结果，在 SE 发作后延迟 2-4 小时. 在 2-3 天内施用六剂选择性 EP2 拮抗剂 TG6-10-1 可加速功能恢复，减轻海马神经变性、神经炎症、神经胶质增生和血脑屏障渗漏，并在不阻断 SE 本身的情况下预防长期认知缺陷或改变急性发作特征。这项工作提供了关于成人中有机磷诱导的癫痫相关病理的重要信息，并揭示了延迟 EP2 抑制对抗这些病理的有效性。