Cyclodextrins (CDs), which are a class of cyclic oligosaccharides extracted from the enzymatic degradation of starch, are often utilized in molecular recognition and assembly constructs, primarily via host-guest interactions in water. In this review, recent progress in CD-based supramolecular nanoassemblies that are sensitive to chemical, biological, and physical stimuli is updated and reviewed, and intriguing examples of the biological functions of these nanoassemblies are presented, including pH- and redox-responsive drug and gene delivery, enzyme-activated specific cargo release, photoswitchable morphological interconversion, microtubular aggregation, and cell-cell communication, as well as a geomagnetism-controlled nanosystem for the suppression of tumor invasion and metastasis. Moreover, future perspectives and challenges in the fabrication of intelligent CD-based biofunctional materials are also discussed at the end of this review, which is expected to promote the translational development of these nanomaterials in the biomedical field.

中文翻译：

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基于环糊精的多刺激响应性超分子组装及其生物学功能。

环糊精（CDs）是从淀粉的酶促降解中提取的一类环状寡糖，通常主要通过宿主-客体在水中的相互作用用于分子识别和组装结构中。在这篇综述中，对化学，生物学和物理刺激敏感的基于CD的超分子纳米组件的最新进展进行了更新和综述，并介绍了这些纳米组件的生物学功能的有趣示例，包括对pH和氧化还原反应敏感的药物和基因传递，酶激活的特定货物释放，光开关形态互转换，微管聚集和细胞间通讯，以及地磁控制的纳米系统可抑制肿瘤的侵袭和转移。而且，