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Low-toxicity amphiphilic molecules linked by an aromatic nucleus show broad-spectrum antibacterial activity and low drug resistance†
Chemical Communications ( IF 4.9 ) Pub Date : 2019-02-15 00:00:00 , DOI: 10.1039/c9cc00857h
Wenchao Chu 1, 2, 3, 4, 5 , Yi Yang 1, 2, 3, 4, 5 , Shangshang Qin 1, 2, 3, 4, 5 , Jianfeng Cai 6, 7, 8, 9 , Mengmeng Bai 1, 2, 3, 4, 5 , Hongtao Kong 1, 2, 3, 4, 5 , En Zhang 1, 2, 3, 4, 5
Affiliation  

Amphiphilic molecules linked by an aromatic nucleus were developed that showed high selectivity toward bacteria over mammalian cells, and low drug resistance. A promising compound 4g exhibited strong bactericidal activity against a panel of sensitive and resistant bacteria, low toxicity, the ability to reduce cell viability in biofilms, stability in mammalian fluids, rapid killing of pathogens, and high in vivo efficacy against methicillin-resistant Staphylococcus aureus (MRSA).

中文翻译:

由芳香核连接的低毒性两亲分子显示广谱抗菌活性和低耐药性

通过芳香核连接的两亲分子被开发出来,对细菌对哺乳动物细胞的选择性高,对药物的抵抗力低。有前途的化合物4g表现出对一组敏感和耐药细菌的强杀菌活性,低毒性,降低生物膜中细胞活力的能力,在哺乳动物液中的稳定性,病原体的快速杀灭以及对耐甲氧西林金黄色葡萄球菌的体内有效性高(MRSA)。
更新日期:2019-02-15
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