In Reply We appreciate the interest of Davido et al in our 2018 publication¹ in JAMA Surgery regarding Clostridium difficile infection (CDI), and we equally appreciate the opportunity provided by the journal to respond to their comments. It is important to note that the impetus for this study rests on in vivo translational work in a murine model of C difficile^2,3 by one of our study collaborators (E.L.B.). This previous work demonstrated that microbiota induction of the cytokine IL-25 protected from death from C difficile colitis via eosinophils. The focus of our studies is the host-pathogen interaction. In particular, we are interested in host response to CDI and how that may predict the development of disease-related adverse events.

在答复中，我们感谢Davido等人在JAMA Surgery的2018年出版物¹中对艰难梭菌感染（CDI）的关注，我们同样感谢该期刊提供了回应他们的评论的机会。这是要注意重要的是推动了这项研究要依赖于在小鼠模型体内翻译工作的艰难^{2 ，3}通过我们的研究合作者之一（ELB）。先前的工作表明，细胞因子IL-25的微生物群诱导可保护其免受艰难梭菌的死亡通过嗜酸性粒细胞引起的结肠炎。我们研究的重点是宿主与病原体的相互作用。特别是，我们对宿主对CDI的反应以及如何预测疾病相关不良事件的发生感兴趣。