We read with great interest the article by Hubers et al published in Gut .1 They identified annexin A11 as an autoantigen in IgG4-associated cholangitis (IAC) and autoimmune pancreatitis (AIP), which is targeted by IgG4 and IgG1 antibodies in the sera of IAC/AIP patients.1 Notably, they reported that none of the 20 patients tested for primary sclerosing cholangitis (PSC) had anti-annexin A11 antibodies. Thus, the measurement of these antibodies is helpful in differentiating IAC from PSC. In addition to the anti-annexin A11 antibodies, we recently reported another autoantibody, anti-laminin 511-E8 antibody, in patients with AIP.2 Here, we show a case of IAC/AIP with a normal serum IgG4 concentration and no infiltration of IgG4 plasma cells in the biliary duct, whose diagnosis was made by measuring the anti-laminin 511-E8 antibody. A 57-year-old man visited our hospital in 2005 for swelling of pancreas. Contrast-enhanced CT and …

中文翻译：

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抗层粘连蛋白511-E8抗体诊断血清IgG4浓度正常的IgG4相关硬化性胆管炎病例：自身免疫性胰腺炎患者的一种新型自身抗体

我们饶有兴趣地阅读了 Hubers 等人发表在 Gut 上的文章。1 他们将膜联蛋白 A11 鉴定为 IgG4 相关胆管炎 (IAC) 和自身免疫性胰腺炎 (AIP) 中的一种自身抗原，其在血清中被 IgG4 和 IgG1 抗体靶向。 IAC/AIP 患者。1 值得注意的是，他们报告了 20 名接受原发性硬化性胆管炎 (PSC) 检测的患者中没有一人具有抗膜联蛋白 A11 抗体。因此，这些抗体的测量有助于区分 IAC 和 PSC。除了抗膜联蛋白 A11 抗体外，我们最近还报道了 AIP 患者的另一种自身抗体，抗层粘连蛋白 511-E8 抗体。胆管中IgG4浆细胞，通过检测抗层粘连蛋白511-E8抗体作出诊断。一名57岁男性因胰腺肿胀于2005年来我院就诊。对比增强 CT 和…