Pancreatic cancer is characterized by an extensive fibroinflammatory reaction that includes immune cells, fibroblasts, extracellular matrix, vascular and lymphatic vessels, and nerves. Overwhelming evidence indicates that the pancreatic cancer microenvironment regulates cancer initiation, progression, and maintenance. Pancreatic cancer treatment has progressed little over the past several decades, and the prognosis remains one of the worst for any cancer. The contribution of the microenvironment to carcinogenesis is a key area of research, offering new potential targets for treating the disease. Here, we explore the composition of the pancreatic cancer stroma, discuss the network of interactions between different components, and describe recent attempts to target the stroma therapeutically. We also discuss current areas of active research related to the tumor microenvironment.

中文翻译：

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胰腺癌中的上皮-间质相互作用。

胰腺癌的特征是广泛的纤维炎性反应，包括免疫细胞，成纤维细胞，细胞外基质，血管和淋巴管以及神经。大量证据表明，胰腺癌微环境调节癌症的发生，发展和维持。在过去的几十年中，胰腺癌的治疗进展甚微，预后仍然是所有癌症中最糟糕的预后之一。微环境对致癌作用的贡献是研究的关键领域，为治疗该疾病提供了新的潜在靶标。在这里，我们探讨了胰腺癌基质的组成，讨论了不同成分之间相互作用的网络，并描述了靶向治疗基质的近期尝试。