Maintenance of a homeostatic body core temperature is a critical brain function accomplished by a central neural network. This orchestrates a complex behavioral and autonomic repertoire in response to environmental temperature challenges or declining energy homeostasis and in support of immune responses and many behavioral states. This review summarizes the anatomical, neurotransmitter, and functional relationships within the central neural network that controls the principal thermoeffectors: cutaneous vasoconstriction regulating heat loss and shivering and brown adipose tissue for heat production. The core thermoregulatory network regulating these thermoeffectors consists of parallel but distinct central efferent pathways that share a common peripheral thermal sensory input. Delineating the neural circuit mechanism underlying central thermoregulation provides a useful platform for exploring its functional organization, elucidating the molecular underpinnings of its neuronal interactions, and discovering novel therapeutic approaches to modulating body temperature and energy homeostasis.

中文翻译：

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温度调节的中心机制。

维持体内稳态温度是通过中央神经网络完成的关键大脑功能。这可以应对环境温度挑战或能量稳态下降，并支持免疫反应和许多行为状态，从而编排复杂的行为和自主功能。这篇综述总结了控制主要热效应器的中央神经网络内的解剖学，神经递质和功能关系：调节热损失和发抖的褐色血管收缩和发热量的褐色脂肪组织。调节这些热效应器的核心温度调节网络由平行但截然不同的中央传出通道组成，这些通道共享一个共同的外围热感觉输入。