Structural DNA nanotechnology takes DNA, a biopolymer, far beyond being the molecule that stores and transmits genetic information in biological systems. DNA has been employed as building blocks for the assembly of designed, nanoscaled, supramolecular DNA architectures for applications in biophysics, structure determination, synthetic biology, diagnostics, and drug delivery. Herein, we review a symmetric approach of tile-based DNA self-assembly. This approach allows the construction of DNA nanostructures from minimal numbers of different types of DNA strands based on sequence and structural symmetries. Some examples of the applications of this approach in siRNA delivery are discussed as well.

中文翻译：

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DNA纳米结构的极简主义方法。

结构性DNA纳米技术采用的是DNA，一种生物聚合物，远远超出了在生物系统中存储和传递遗传信息的分子。DNA已被用作组装设计的，纳米级，超分子DNA结构的基础，这些结构可用于生物物理学，结构确定，合成生物学，诊断和药物输送。在本文中，我们回顾了基于图块的DNA自组装的对称方法。这种方法允许根据序列和结构对称性，由最少数量的不同类型的DNA链构建DNA纳米结构。还讨论了该方法在siRNA递送中的一些应用实例。