Doxorubicin (DOX), an anthracycline molecule, is currently one of the most widely used anticancer drugs in clinics. Systematic treatment of patients with DOX is known to be accompanied by several unpleasant side effects due to the toxicity of the drug. Thus, monitoring of DOX concentration in serum samples has become increasingly important to avoid side effects and ensure therapeutic efficiency. In this study, we discuss the construction of a disposable electrochemical sensor for the direct monitoring of DOX in clinical blood samples. The sensor is based on coating a gold electrode in a flexible integrated electrode construct formed on polyimide sheets using photolithography, with nitrogen-doped reduced graphene oxide (N-rGO) suspended in chitosan. Under optimized conditions, a linear relationship between the oxidative peak current and the concentration of DOX in the range of 0.010–15 μM with a detection limit of 10 nM could be achieved. The sensor was adapted to monitor DOX in serum samples of patients under anticancer treatment.

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阿霉素分子阿霉素（DOX）是目前临床上使用最广泛的抗癌药物之一。已知由于药物的毒性，对DOX患者的系统治疗伴随有几种令人不快的副作用。因此，监测血清样品中DOX浓度对于避免副作用和确保治疗效率变得越来越重要。在这项研究中，我们讨论了用于直接监测临床血液样本中DOX的一次性电化学传感器的构造。该传感器基于使用光刻技术在聚酰亚胺板上形成的柔性集成电极构造中的金电极上涂覆氮掺杂的还原氧化石墨烯（N-rGO）悬浮在壳聚糖中而成的。在优化条件下，氧化峰值电流与DOX浓度在0.010-15μM范围内，检测限为10nM之间可建立线性关系。该传感器适用于监测接受抗癌治疗的患者血清样品中的DOX。

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