Psoriatic arthritis (PsA) is a heterogeneous chronic inflammatory musculoskeletal condition with complex pathophysiology. In recent years, understanding of the pathogenesis of PsA has improved substantially. Several genetic and inflammatory factors have been identified and studied as targets for new biologic disease-modifying therapies. This review presents findings from a detailed literature assessment conducted to identify genes and biomarkers associated with PsA and its most common comorbidities. This literature assessment identifies genes and biomarkers that may be predictive of the onset and severity of PsA, places them in the context of our understanding of PsA pathogenesis, and explores potential connections between the pathways involved in PsA and current biologic therapeutics used to treat PsA. Knowledge of the genetics and inflammatory factors associated with disease pathogenesis can support the targeted development of new biologic therapies and biomarkers for PsA.

中文翻译：

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与银屑病关节炎相关的遗传和炎性因素：与诊断和管理的相关性。

银屑病关节炎（PsA）是一种具有复杂病理生理学的异质性慢性炎症性骨骼肌疾病。近年来，人们对PsA的发病机理的认识已大大提高。已经鉴定和研究了几种遗传和炎性因子，作为新的生物疾病缓解疗法的靶标。这项审查提出了详细的文献评估，以鉴定与PsA及其最常见的合并症相关的基因和生物标记物的发现。这项文献评估确定了可预测PsA发病和严重程度的基因和生物标记物，将其置于我们对PsA发病机理的理解中，并探讨了PsA涉及的途径与当前用于治疗PsA的生物疗法之间的潜在联系。