Low expression of caveolin-1 (Cav-1) is typical in psoriatic lesions and overexpression of Cav-1 leads to a reduction of inflammation and suppression of epidermal hyperproliferation, thus ameliorating these two well-known hallmarks of psoriasis. At the same time, the interfacial layers of the white adipose tissue (WAT) adjacent to psoriatic lesions demonstrate much higher stiffness, which also points to a modification of Cav-1 expression in this tissue. These processes are connected with each other and regulated via exosomal exchange. Here we discuss the role of Cav-1 expression in inflammatory and hyperproliferative processes and analyze the ways to provide spatially different modulation of Cav-1 expression in the skin and WAT. Such modulation can be induced by different pharmacological and physical factors. These include application of mechanical stress and supra-physiological temperatures. Cav-1 should therefore be considered as an important target in treatment of psoriasis.

Caveolin-1（Cav-1）的低表达是典型的银屑病病灶，Cav-1的过表达导致炎症减轻和表皮过度增殖的抑制，从而减轻了牛皮癣的这两个众所周知的特征。同时，与牛皮癣病变相邻的白色脂肪组织（WAT）的界面层显示出更高的刚度，这也表明该组织中Cav-1表达的改变。这些过程相互联系，并通过外泌体交换进行调控。在这里，我们讨论了Cav-1表达在炎症和过度增殖过程中的作用，并分析了在皮肤和WAT中提供Cav-1表达在空间上不同的调节方式。可以通过不同的药理和物理因素来诱导这种调节。这些包括施加机械应力和超生理温度。因此，Cav-1应被视为治疗牛皮癣的重要靶标。