Long noncoding RNAs (lncRNAs) have increasingly been shown to be important biological regulators involved in numerous diseases. Further, increasing evidence demonstrates that circulating lncRNAs can be used as diagnostic biomarkers. Therefore, the purpose of this study was to evaluate the potential for circulating lncRNAs as novel biomarkers for the diagnosis of preeclampsia. In the present study, we measured the expression of five lncRNAs known to be relevant to the uterus in whole blood samples from 48 preeclampsia patients and 24 non-preeclampsia healthy subjects using qRT-PCR. We found that circulating levels of lncRNA BC030099 were significantly higher in patients with preeclampsia (1.232 ± 0.4870) than in non-preeclampsia healthy subjects (0.9928 ± 0.2008, p < 0.05). The area under the receiver operating characteristic (ROC) curve for lncRNA BC030099 was 0.713. Univariate and multivariate analyses identified lncRNA BC030099 as an independent predictor for preeclampsia. In brief, our results suggest that increased plasma levels of lncRNA BC030099 are associated with an increased risk of preeclampsia and may be considered a novel biomarker.

长非编码RNA（lncRNA）越来越多地显示出是参与多种疾病的重要生物调节剂。此外，越来越多的证据表明循环中的lncRNA可以用作诊断生物标志物。因此，本研究的目的是评估循环lncRNAs作为诊断先兆子痫的新型生物标志物的潜力。在本研究中，我们使用qRT-PCR测量了48位先兆子痫患者和24位非先兆子痫健康受试者的全血样品中与子宫相关的5种lncRNA的表达。我们发现子痫前期患者的lncRNA BC030099循环水平显着高于非子痫前期健康受试者（0.9928±0.2008，p <0.05）。lncRNA BC030099的受体工作特征（ROC）曲线下方的面积为0.713。单因素和多因素分析确定lncRNA BC030099是先兆子痫的独立预测因子。简而言之，我们的结果表明，lncRNA BC030099的血浆水平升高与先兆子痫的风险增加相关，并且可以被认为是一种新型的生物标志物。