Acral lentiginous melanoma is a distinct subtype of melanoma on acral skin. Patient presentation at later stages and delayed diagnosis by physicians contribute to a worse associated prognosis and survival rate. Despite our progress in understanding the key features of this disease, the diagnosis of early-stage acral melanoma is still challenging. It is essential to integrate clinical, dermoscopic, and histologic findings in the diagnosis of acral lentiginous melanoma. In addition, molecular studies can be helpful. In this review, we have summarized our current understanding of this disease entity from articles that were published between 1969 and 2018. We have outlined clinical and dermoscopic features as well as pathologic and molecular findings regarding acral melanoma and have presented an algorithm for diagnosis. Understanding and integrating these characteristics may assist clinicians in the early detection of acral melanomas.

中文翻译：

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早期发现急性黑色素瘤：临床，皮肤镜，组织病理学和分子学特征的综述。

肢端黑色素性黑色素瘤是肢端皮肤上黑色素瘤的独特亚型。患者在较晚阶段的就诊和医生的延迟诊断会导致相关的预后和生存率变差。尽管我们在了解这种疾病的关键特征方面取得了进步，但是早期的急性阑尾黑色素瘤的诊断仍然具有挑战性。整合临床，皮肤镜检查和组织学检查结果对于诊断手足性慢性黑色素瘤至关重要。此外，分子研究可能会有所帮助。在这篇综述中，我们从1969年至2018年之间发表的文章中总结了我们对该疾病实体的当前理解。我们概述了有关急性黑素瘤的临床和皮肤镜特征以及病理和分子发现，并提出了一种诊断算法。