Methylene violet 3RAX-conjugated porphyrin for photodynamic therapy: synthesis, DNA photocleavage, and cell study†,RSC Advances

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Methylene violet 3RAX-conjugated porphyrin for photodynamic therapy: synthesis, DNA photocleavage, and cell study†
RSC Advances ( IF 3.9 ) Pub Date : 2018-01-24 00:00:00 , DOI: 10.1039/c7ra13176c
Si Yao _{1,

2,

3,

4,

5} , Yunman Zheng _{4,

5,

6,

7} , Lijun Jiang _{5,

8,

9} , Chen Xie _{5,

8,

9} , Fengshou Wu _{4,

5,

10,

11} , Chi Huang _{4,

5,

6,

7} , Xiong Zhang _{4,

5,

10,

11} , Ka-Leung Wong _{5,

8,

9,

12,

13} , Zaoying Li _{4,

5,

6,

7} , Kai Wang _{1,

2,

3,

4,

5}

Affiliation

A methylene violet 3RAX-conjugated porphyrin has been designed and synthesized as a potential photosensitizer in photodynamic therapy because of its high DNA binding constant and the efficacy in inhibiting cancer cells with subcellular localization.

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