Fungal Biology Reviews ( IF 6 ) Pub Date : 2017-10-05 , DOI: 10.1016/j.fbr.2017.09.002 Fabianno F. Dutra , Priscila C. Albuquerque , Marcio L. Rodrigues , Fernanda L. Fonseca
Cryptococcus neoformans and Cryptococcus gatti are the etiological agents of cryptococcosis, a life-threatening mycosis affecting the central nervous system. Cryptococcal meningoencephalitis is the most fatal mycosis in AIDS patients, resulting almost 200 000 deaths annually. High cost, side effects and drug resistance are constant elements during treatment of cryptococcosis, encouraging the development of novel therapeutic strategies including immunomodulatory protocols. Thereby, to understand how the host responds to Cryptococcus is essential. In this review, we discuss the immune response against Cryptococcus and immunoevasion strategies.
中文翻译:
战争与防御:宿主对隐球菌感染的反应
新型隐球菌和隐球菌加蒂是隐球菌病,威胁生命的真菌病影响中枢神经系统的病原。隐球菌脑膜脑炎是艾滋病患者中最致命的真菌病,每年导致近20万人死亡。高成本,副作用和耐药性是隐球菌病治疗期间的基本要素,这鼓励了包括免疫调节方案在内的新型治疗策略的发展。因此,了解宿主如何响应隐球菌至关重要。在这篇综述中,我们讨论了针对隐球菌的免疫反应和免疫逃避策略。