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Food-grade cationic antimicrobial ε-polylysine transiently alters the gut microbial community and predicted metagenome function in CD-1 mice
npj Science of Food ( IF 6.4 ) Pub Date : 2017-12-18 , DOI: 10.1038/s41538-017-0006-0
Xiaomeng You , Jonah E. Einson , Cynthia Lyliam Lopez-Pena , Mingyue Song , Hang Xiao , David Julian McClements , David A. Sela

Diet is an important factor influencing the composition and function of the gut microbiome, but the effect of antimicrobial agents present within foods is currently not understood. In this study, we investigated the effect of the food-grade cationic antimicrobial ε-polylysine on the gut microbiome structure and predicted metagenomic function in a mouse model. The relative abundances of predominant phyla and genera, as well as the overall community structure, were perturbed in response to the incorporation of dietary ε-polylysine. Unexpectedly, this modification to the gut microbiome was experienced transiently and resolved to the initial basal composition at the final sampling point. In addition, a differential non-random assembly was observed in the microbiomes characterized from male and female co-housed animals, although their perturbation trajectories in response to diet remain consistent. In conclusion, antimicrobial ε-polylysine incorporated into food systems transiently alters gut microbial communities in mice, as well as their predicted function. This indicates a dynamic but resilient microbiome that adapts to microbial-active dietary components.



中文翻译:

食品级阳离子抗微生物ε-聚赖氨酸可瞬时改变肠道微生物群落并预测CD-1小鼠的基因组功能

饮食是影响肠道微生物组组成和功能的重要因素,但是目前尚不清楚食物中存在的抗菌剂的作用。在这项研究中,我们调查了食品级阳离子抗微生物ε-聚赖氨酸对肠道微生物组结构的影响,并预测了小鼠模型中的宏基因组功能。饮食中的ε-聚赖氨酸的加入会扰乱主要门和属的相对丰度以及整体群落结构。出乎意料的是,这种对肠道微生物组的修饰是短暂经历的,并在最终的采样点分解为初始的基础成分。此外,在以雄性和雌性共同饲养动物为特征的微生物群落中观察到了不同的非随机装配,尽管它们对饮食的摄动轨迹保持一致。总之,掺入食物系统中的抗菌素ε-聚赖氨酸会暂时改变小鼠的肠道微生物群落及其预测功能。这表明一种动态但有弹性的微生物组可以适应微生物活性的饮食成分。

更新日期:2019-11-18
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