NRPT is a combination of nicotinamide riboside (NR), a nicotinamide adenine dinucleotide (NAD⁺⁾ precursor vitamin found in milk, and pterostilbene (PT), a polyphenol found in blueberries. Here, we report this first-in-humans clinical trial designed to assess the safety and efficacy of a repeat dose of NRPT (commercially known as Basis). NRPT was evaluated in a randomized, double-blind, and placebo-controlled study in a population of 120 healthy adults between the ages of 60 and 80 years. The study consisted of three treatment arms: placebo, recommended dose of NRPT (NRPT 1X), and double dose of NRPT (NRPT 2X). All subjects took their blinded supplement daily for eight weeks. Analysis of NAD⁺ in whole blood demonstrated that NRPT significantly increases the concentration of NAD⁺ in a dose-dependent manner. NAD⁺ levels increased by approximately 40% in the NRPT 1X group and approximately 90% in the NRPT 2X group after 4 weeks as compared to placebo and baseline. Furthermore, this significant increase in NAD⁺ levels was sustained throughout the entire 8-week trial. NAD⁺ levels did not increase for the placebo group during the trial. No serious adverse events were reported in this study. This study shows that a repeat dose of NRPT is a safe and effective way to increase NAD⁺ levels sustainably.

NRPT是牛奶中发现的烟酰胺腺嘌呤二核苷酸（NAD ^+）前体维生素烟酰胺核糖（NR）和蓝莓中发现的多酚蝶呤（PT）的组合。在这里，我们报告了这项人类首次临床试验，旨在评估重复剂量NRPT（商业上称为基础）的安全性和有效性。在一项随机，双盲和安慰剂对照研究中对NRPT进行了评估，研究对象是120位年龄在60至80岁之间的健康成年人。该研究包括三个治疗组：安慰剂，推荐剂量的NRPT（NRPT 1X）和双剂量的NRPT（NRPT 2X）。所有受试者每天服用他们的盲法补品，持续八周。全血中NAD ^+的分析表明NRPT显着增加了NAD的浓度⁺呈剂量依赖性。与安慰剂和基线相比，NRPT 1X组的NAD ⁺水平在4周后增加了约40％，NRPT 2X组的NAD ⁺水平增加了约90％。此外，在整个8周的试验中，NAD ⁺水平的显着增加一直持续。在试验期间，安慰剂组的NAD ⁺水平并未增加。在这项研究中没有报告严重的不良事件。这项研究表明，重复服用NRPT是持续增加NAD ⁺水平的一种安全有效的方法。