Gut microbes are now considered as key partners involved in human physiology. Data have shown that microbes contribute to regulate energy, lipid, and glucose homeostasis through several mechanisms. Among them, the role of pathogen-associated molecular pattern and bacterial metabolites has been proposed (for example, metabolic endotoxemia and bioactive lipids). This short review, briefly discusses the role of the gut barrier as well as the impact of both the innate immune system and bioactive molecules (for example, endocannabinoids, cytochrome P450 derived arachidonic acids compounds) in the framework of gut microbes and cardiometabolic disorders.

中文翻译：

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肠道微生物和宿主细胞之间的相互作用控制肠道屏障和新陈代谢

肠道微生物现在被认为是参与人体生理学的关键伙伴。数据表明，微生物通过多种机制有助于调节能量、脂质和葡萄糖稳态。其中，已经提出了病原体相关分子模式和细菌代谢物的作用（例如，代谢性内毒素血症和生物活性脂质）。这篇简短的综述简要讨论了肠道屏障的作用以及先天免疫系统和生物活性分子（例如，内源性大麻素、细胞色素 P450 衍生的花生四烯酸化合物）在肠道微生物和心脏代谢疾病框架中的影响。