A water-soluble porphyrin, 5,10,15,20-tetrakis[3,4-bis(carboxymethyleneoxy)phenyl] porphyrin (T3,4BCPP), was successfully labeled with 99 m Tc and biodistribution studies were performed in Wistar rats. Scintiimaging and in vivo distribution studies were also carried out in C 6-gliomas and mammary tumor-bearing animals using a gamma camera. Tumor-to-muscle (T/M) ratios were calculated and compared with those obtained with the known tumor-seeking radiopharmaceuticals 99 m Tc (V)- DMSA (DMSA = dimercaptosuccinic acid), 99 m Tc -citrate and 201 TlCl . In the case of C 6-gliomas, the ratios were 4.2, 2.2, 4.00 and 3.0; while in the case of C 3 H / J mammary tumor, the ratios were 9.4, 8.8, 8.1 and 8.5 for T3,4BCPP, 99 m Tc ( V )- DMSA , 99 m Tc -citrate and 201 TlCl , respectively. Similar studies were carried out in N-methyl-N-nitrosourea ( NMU )-induced mammary tumor animals and the T/M ratios obtained were 5.9, 2.0, 5.3 and 3.3 for T3,4BCPP, 99 m Tc ( V )- DMSA , 99 m Tc -citrate and 201 TlCl , respectively. The radiolabeled photosensitizer could perhaps be used to detect cancer non-invasively and could even prove useful in monitoring the progression/regression of tumors before, during, and after chemotherapy, radiation therapy or photodynamic therapy (PDT).

中文翻译：

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锝99m-卟啉（T3,4BCPP）用于肿瘤成像的评价研究

一种水溶性卟啉 5,10,15,20-四[3,4-双(羧甲氧基)苯基]卟啉 (T3,4BCPP) 被成功标记为99 米在 Wistar 大鼠中进行 Tc 和生物分布研究。闪烁成像和体内分布研究也在 C 中进行6- 使用伽马相机的神经胶质瘤和携带乳腺肿瘤的动物。计算了肿瘤与肌肉 (T/M) 的比值，并与使用已知的寻找肿瘤的放射性药物获得的比值进行比较99 米Tc (V)- DMSA (DMSA = 二巯基琥珀酸),99 米Tc-柠檬酸盐和201氯化铊。在 C 的情况下6-胶质瘤，比率为4.2、2.2、4.00和3.0；而在 C 的情况下3H / J乳腺肿瘤，T3、4BCPP的比率分别为9.4、8.8、8.1和8.5，99 米Tc (V)-DMSA ,99 米Tc-柠檬酸盐和201TlCl 分别。在 N-甲基-N-亚硝基脲 (NMU) 诱导的乳腺肿瘤动物中进行了类似的研究，获得的 T/M 比为 5.9、2.0、5.3 和 3.3，T3、4BCPP、99 米Tc (V)-DMSA ,99 米Tc-柠檬酸盐和201TlCl 分别。放射性标记的光敏剂或许可用于非侵入性检测癌症，甚至可用于监测化疗、放疗或光动力疗法 (PDT) 之前、期间和之后的肿瘤进展/消退。