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Magnetically driven nanoparticles: 18FDG‐radiolabelling and positron emission tomography biodistribution study
Contrast Media & Molecular Imaging ( IF 3.009 ) Pub Date : 2017-01-04 , DOI: 10.1002/cmmi.1718
Mariarosaria De Simone 1 , Daniele Panetta 1 , Emilia Bramanti 2 , Cristiana Giordano 3, 4 , Maria C. Salvatici 3 , Lisa Gherardini 1 , Arianna Menciassi 5 , Silvia Burchielli 6 , Caterina Cinti 1 , Piero A. Salvadori 1
Affiliation  

Superparamagnetic iron oxide nanoparticles (SPIONs) have received increasing interest as contrast media in biomedical imaging and innovative therapeutic tools, in particular for loco‐regional ablative treatments and drug delivery. The future of therapeutic applications would strongly benefit from improving the capability of the nanostructured constructs to reach the selected target, in particular beyond the intravascular space. Besides the decoration of SPIONs surface with ad hoc bioactive molecules, external magnetic fields are in principle able to remotely influence SPIONs’ physiological biodistribution and concentrate them to a specific anatomical region or portion of a tissue. The reduction of SPIONs administered to the body and the need for defining the effective SPIONs local concentration suggest that PET/CT may be a method to quantitatively detect the nanoparticles accumulation in vivo at low concentration and assess their tridimensional distribution in response to an external magnetic field and in relation to the local anatomy highlighted by CT imaging. Here, we report on the possibility to assess the spatial distribution of magnetically‐driven radiolabelled SPIONs in a peripheral tissue (mouse thigh) with microPET/CT imaging. To this aim we labelled SPIONs using 18F‐2‐fluoro‐2‐deoxyglucose as a synthon, by chemoselective oxime formation between its open‐chain tautomer and nanoparticle amino‐groups, and employed microPET/CT imaging to measure the radiolabelled construct biodistribution in a small animal model, following intravenous administration, with and without the application of a permanent magnet onto the skin. The in vivo and ex vivo results showed that micro‐PET/CT was able to demonstrate the localizing action of the magnet on SPIONs and provide information, in a multimodal 3D data set, about SPIONs biodistribution taking into account the local anatomy. Copyright © 2017 John Wiley & Sons, Ltd.

中文翻译:

磁性驱动的纳米粒子:18FDG放射放射和正电子发射断层扫描生物分布研究

作为生物医学成像和创新治疗工具中的造影剂,超顺磁性氧化铁纳米颗粒(SPIONs)引起了越来越多的兴趣,特别是在局部区域消融治疗和药物递送方面。未来的治疗应用将极大地受益于提高纳米结构构建体达到所选靶标的能力,特别是在血管内空间之外的靶标。除了用特殊的生物活性分子修饰SPIONs表面外,原则上外部磁场还可以远程影响SPIONs的生理生物分布并将它们集中到组织的特定解剖区域或部分。低浓度体内,并评估它们的三维分布,以响应外部磁场以及与CT成像突出显示的局部解剖结构有关。在这里,我们报告了通过microPET / CT成像评估外周组织(小鼠大腿)中磁性驱动的放射性标记SPIONs的空间分布的可能性。为此,我们使用18 F-2-氟-2-脱氧葡萄糖作为合成子,通过其开链互变异构体和纳米颗粒氨基之间的化学选择性肟形成标记了SPIONs ,并使用microPET / CT成像来测量放射性标记的构建体在体内的生物分布。静脉给药后,有或没有在皮肤上施加永磁体的小型动物模型。在体内离体结果表明,micro-PET / CT能够证明磁体对SPIONs的定位作用,并在多模式3D数据集中提供了考虑到局部解剖结构的SPIONs生物分布信息。版权所有©2017 John Wiley&Sons,Ltd.
更新日期:2017-01-04
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