The suitability of controlled stress large amplitude oscillatory shear (LAOStress) for the characterisation of the nonlinear viscoelastic properties of fully formed fibrin clots is investigated. Capturing the rich nonlinear viscoelastic behaviour of the fibrin network is important for understanding the structural behaviour of clots formed in blood vessels which are exposed to a wide range of shear stresses. We report, for the first time, that artefacts due to ringing exist in both the sample stress and strain waveforms of a LAOStress measurement which will lead to errors in the calculation of nonlinear viscoelastic properties. The process of smoothing the waveforms eliminates these artefacts whilst retaining essential rheological information. Furthermore, we demonstrate the potential of LAOStress for characterising the nonlinear viscoelastic properties of fibrin clots in response to incremental increases of applied stress up to the point of fracture. Alternating LAOStress and small amplitude oscillatory s...

中文翻译：

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大振幅振荡应力在完全形成的纤维蛋白凝块研究中的应用

研究了控制应力大振幅振荡剪切 (LAOStress) 的适用性，用于表征完全形成的纤维蛋白凝块的非线性粘弹性。捕捉纤维蛋白网络丰富的非线性粘弹性行为对于理解暴露于各种剪切应力的血管中形成的凝块的结构行为非常重要。我们首次报告说，由于振铃而导致的人工制品存在于 LAOStress 测量的样本应力和应变波形中，这将导致非线性粘弹性计算中的错误。平滑波形的过程消除了这些伪影，同时保留了基本的流变信息。此外，我们证明了 LAOStress 在表征纤维蛋白凝块的非线性粘弹性特性方面的潜力，以响应施加应力的增量增加直至断裂点。交替 LAOStress 和小振幅振荡...