Particular lipid profiles have been found in two different protozoa of the Leishmania genus. Leishmania infantum, a visceral leishmaniasis causative agent and Leishmania amazonensis, a cutaneous leishmaniasis, reveal distinctive lipid contents of phosphatidylethanolamine and phosphatidylserine plasmalogens, sphingolipids, phosphatidylinositols, phosphatidylcholine, and phosphatidylethanolamine, which have been shown to be related to species, life-cycle of the parasite, and macrophage infection. L. infantum displayed a higher content of phosphatidylethanolamine plasmalogens than L. amazonensis, which may help to differentiate their unique clinical manifestations. Phosphatidylserines plasmalogens are also found to be an important lipid class for the intracellular form of the parasite. Our findings also reveal lipid classes that may be involved in visceralization pathways and parasite differentiation.

中文翻译：

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婴儿乳杆菌和亚马逊乳杆菌体外巨噬细胞感染的脂质学变化

在利什曼原虫属的两个不同的原生动物中发现了特定的脂质谱。内脏利什曼病的病原体婴儿利什曼原虫和皮肤利什曼病的亚马逊利什曼原虫表现出磷脂酰乙醇胺和磷脂酰丝氨酸血浆缩醛磷脂，鞘脂，磷脂酰肌醇，磷脂酰胆碱和与磷脂酰乙醇胺有关的种类的磷脂，寄生虫和巨噬细胞感染。婴儿乳杆菌显示的磷脂酰乙醇胺缩醛磷脂含量高于亚马逊乳杆菌，这可能有助于区分其独特的临床表现。还发现磷脂酰丝氨酸缩醛磷脂是寄生虫的细胞内形式的重要脂质类别。我们的发现还揭示了可能与内脏化途径和寄生虫分化有关的脂质类别。