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The Ecology of Prions
Microbiology and Molecular Biology Reviews ( IF 12.9 ) Pub Date : 2017-05-31 , DOI: 10.1128/mmbr.00001-17
Mark Zabel 1 , Aimee Ortega 1
Affiliation  

SUMMARY Chronic wasting disease (CWD) affects cervids and is the only known prion disease readily transmitted among free-ranging wild animal populations in nature. The increasing spread and prevalence of CWD among cervid populations threaten the survival of deer and elk herds in North America, and potentially beyond. This review focuses on prion ecology, specifically that of CWD, and the current understanding of the role that the environment may play in disease propagation. We recount the discovery of CWD, discuss the role of the environment in indirect CWD transmission, and consider potentially relevant environmental reservoirs and vectors. We conclude by discussing how understanding the environmental persistence of CWD lends insight into transmission dynamics and potential management and mitigation strategies.



中文翻译:

ions病毒的生态

发明内容慢性消耗性疾病(CWD)影响子宫颈,并且是自然界中自由散布的野生动物种群中容易传播的唯一已知的病毒疾病。CWD在特定人群中的传播和流行程度不断提高,威胁到北美乃至其他地区鹿和麋鹿种群的生存。这篇综述的重点是病毒的生态学,特别是CWD的生态学,以及对环境在疾病传播中可能扮演的角色的当前理解。我们叙述了CWD的发现,讨论了环境在CWD间接传播中的作用,并考虑了潜在的相关环境储层和媒介。最后,我们通过讨论如何理解CWD的环境持久性来深入了解传动动态以及潜在的管理和缓解策略。

更新日期:2017-08-31
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