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Thrombus Formation at High Shear Rates
Annual Review of Biomedical Engineering ( IF 9.7 ) Pub Date : 2017-06-20 00:00:00 , DOI: 10.1146/annurev-bioeng-071516-044539
Lauren D.C. Casa 1 , David N. Ku 1
Affiliation  

The final common pathway in myocardial infarction and ischemic stroke is occlusion of blood flow from a thrombus forming under high shear rates in arteries. A high-shear thrombus forms rapidly and is distinct from the slow formation of coagulation that occurs in stagnant blood. Thrombosis at high shear rates depends primarily on the long protein von Willebrand factor (vWF) and platelets, with hemodynamics playing an important role in each stage of thrombus formation, including vWF binding, platelet adhesion, platelet activation, and rapid thrombus growth. The prediction of high-shear thrombosis is a major area of biofluid mechanics in which point-of-care testing and computational modeling are promising future directions for clinically relevant research. Further research in this area will enable identification of patients at high risk for arterial thrombosis, improve prevention and treatment based on shear-dependent biological mechanisms, and improve blood-contacting device design to reduce thrombosis risk.

中文翻译:


高剪切速率下的血栓形成

心肌梗塞和局部缺血性卒中的最终通用途径是在高剪切速率下动脉血栓形成时血流的阻塞。高剪切血栓迅速形成,与停滞血液中缓慢形成的凝血不同。高剪切速率下的血栓形成主要取决于长蛋白von Willebrand因子(vWF)和血小板,血流动力学在血栓形成的每个阶段都起着重要作用,包括vWF结合,血小板粘附,血小板活化和快速血栓生长。高剪切血栓形成的预测是生物流体力学的一个主要领域,其中即时检验和计算模型是临床相关研究的有希望的未来方向。

更新日期:2017-06-20
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