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Ammonia free partial reduction of aromatic compounds using lithium di-tert-butylbiphenyl (LiDBB).
The Journal of Organic Chemistry ( IF 3.6 ) Pub Date : 2002 Jul 12
Donohoe, Timothy J, House, David

The reduction of a series of hetero- and carbocyclic aromatic compounds under ammonia free conditions is described. By using LiDBB as a source of electrons, bis(methoxyethyl)amine (BMEA) as a protonating agent, and THF as a solvent, we were able to accomplish reductions more usually performed under Birch type conditions. Moreover, the use of these conditions was further enhanced by the tolerance of the reducing system toward reactive electrophiles that cannot be used successfully in ammonia.

中文翻译:

使用二叔丁基联苯锂(LiDBB)无氨部分还原芳族化合物。

描述了在无氨条件下一系列杂环和碳环芳族化合物的还原。通过使用LiDBB作为电子源,使用双(甲氧基乙基)胺(BMEA)作为质子化剂,使用THF作为溶剂,我们能够更通常地在Birch型条件下完成还原反应。此外,通过还原系统对不能在氨中成功使用的反应性亲电试剂的耐受性,进一步提高了这些条件的使用率。
更新日期:2017-01-31
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