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Multianalyte Physiological Microanalytical Devices
Annual Review of Analytical Chemistry ( IF 8 ) Pub Date : 2017-06-12 00:00:00 , DOI: 10.1146/annurev-anchem-061516-045334
Anna Nix Davis 1 , Adam R Travis 1 , Dusty R Miller 1 , David E Cliffel 1, 2
Affiliation  

Advances in scientific instrumentation have allowed experimentalists to evaluate well-known systems in new ways and to gain insight into previously unexplored or poorly understood phenomena. Within the growing field of multianalyte physiometry (MAP), microphysiometers are being developed that are capable of electrochemically measuring changes in the concentration of various metabolites in real time. By simultaneously quantifying multiple analytes, these devices have begun to unravel the complex pathways that govern biological responses to ischemia and oxidative stress while contributing to basic scientific discoveries in bioenergetics and neurology. Patients and clinicians have also benefited from the highly translational nature of MAP, and the continued expansion of the repertoire of analytes that can be measured with multianalyte microphysiometers will undoubtedly play a role in the automation and personalization of medicine. This is perhaps most evident with the recent advent of fully integrated noninvasive sensor arrays that can continuously monitor changes in analytes linked to specific disease states and deliver a therapeutic agent as required without the need for patient action.

中文翻译:


多分析物生理微量分析设备

科学仪器的进步使实验者能够以新的方式评估众所周知的系统,并深入了解以前未探索或知之甚少的现象。在不断发展的多分析物生理测量 (MAP) 领域中,正在开发能够以电化学方式实时测量各种代谢物浓度变化的微生理计。通过同时量化多种分析物,这些设备已经开始解开控制对缺血和氧化应激的生物反应的复杂途径,同时促进生物能量学和神经学的基础科学发现。患者和临床医生也受益于 MAP 的高度转化性,以及可以用多分析物微生理计测量的分析物库的持续扩展无疑将在医学的自动化和个性化方面发挥作用。这一点在最近出现的完全集成的无创传感器阵列中最为明显,该阵列可以持续监测与特定疾病状态相关的分析物的变化,并根据需要提供治疗剂,而无需患者采取行动。

更新日期:2017-06-12
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