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Dysregulated innate immune signaling cooperates with RUNX1 mutations to transform an MDS-like disease to AML iScience (IF 5.8) Pub Date : 2024-04-24 Laura Barreyro, Avery M. Sampson, Kathleen Hueneman, Kwangmin Choi, Susanne Christie, Vighnesh Ramesh, Michael Wyder, Dehua Wang, Mario Pujato, Ken Greis, Gang Huang, Daniel T. Starczynowski
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Mitochondrial F0F1-ATP synthase governs the induction of mitochondrial fission iScience (IF 5.8) Pub Date : 2024-04-24 Charlène LHUISSIER, Valérie DESQUIRET-DUMAS, Anaïs GIRONA, Jennifer ALBAN, Justine FAURE, Julien CASSEREAU, Philippe CODRON, Guy LENAERS, Olivier R. BARIS, Naïg GUEGUEN, Arnaud CHEVROLLIER
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Deinonychosaur trackways in southeastern China record a possible giant troodontid iScience (IF 5.8) Pub Date : 2024-04-24 Lida Xing, Kecheng Niu, Martin G. Lockley, Anthony Romilio, Ke Deng, W. Scott Persons
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ALK inhibitors suppress HCC and synergize with anti-PD-1 therapy and ABT-263 in preclinical models iScience (IF 5.8) Pub Date : 2024-04-23 Suresh Bugide, Dhana Sekhar Reddy, Parmanand Malvi, Romi Gupta, Narendra Wajapeyee
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The Application of Large Language Models in Medicine: A Scoping Review iScience (IF 5.8) Pub Date : 2024-04-23 Xiangbin Meng, Xiangyu Yan, Kuo Zhang, Da Liu, Xiaojuan Cui, Yaodong Yang, Muhan Zhang, Chunxia Cao, Jingjia Wang, Xuliang Wang, Jun gao, Yuan-geng-shuo Wang, Jia-ming Ji, Zifeng Qiu, Muzi Li, Cheng Qian, Tianze Guo, Shuangquan Ma, Zeying Wang, Zexuan Guo, Yi-Da Tang
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Optimized Lipid Nanoparticles (LNPs) for Organ-Selective Nucleic Acids Delivery In Vivo iScience (IF 5.8) Pub Date : 2024-04-23 Tian Zhang, Han Yin, Yu Li, Haiyin Yang, Kun Ge, Jinchao Zhang, Qing Yuan, Xuyan Dai, Abid Naeem, Yuhua Weng, Yuanyu Huang, Xing-Jie Liang
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Dual Hybrid Frameworks Combining Graph Convolutional Network with Decoding for Covering Location Problem iScience (IF 5.8) Pub Date : 2024-04-23 Yao Zhang, Shaohua Wang, Haojian Liang, Xiao Li, Zhenbo Wang, Hao Lu
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Discovery of SOCS7 as a versatile E3 ligase for protein-based degraders iScience (IF 5.8) Pub Date : 2024-04-23 Anaïs Cornebois, Marie Sorbara, Margot Cristol, Emmanuelle Vigne, Pierre Cordelier, Klervi Desrumeaux, Nicolas Bery
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Phase 1b Study of Batiraxcept in Combination with Durvalumab in Patients with Platinum-Resistant Ovarian Cancer iScience (IF 5.8) Pub Date : 2024-04-23 Anne Knisely, Emily M. Hinchcliff, Elisabeth Gardiner, Reshma Rangwala, Kathryn Lito, Bryan Fellman, Ying Yuan, Anil K. Sood, Shannon N. Westin, Karen H. Lu, Amir A. Jazaeri
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Increased innate immune responses in adolescents with obesity and its relation to subclinical cardiovascular measures: an exploratory study iScience (IF 5.8) Pub Date : 2024-04-23 Siroon Bekkering, Christoph Saner, Boris Novakovic, Toby Mansell, Danielle K. Longmore, Zoe McCallum, Anne-Louise Ponsonby, Markus Juonala, Mihai G. Netea, Matthew A. Sabin, Richard Saffery, Niels P. Riksen, David P. Burgner
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The social microbiome: the missing mechanism mediating the sociality-fitness nexus? iScience (IF 5.8) Pub Date : 2024-04-23 Alice Baniel, Marie J.E. Charpentier
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Zanubrutinib delays selinexor resistance evolution in biopsy sample-derived primary central nervous system lymphoma models iScience (IF 5.8) Pub Date : 2024-04-23 Xiaohong Zheng, Can Wang, Feng Chen, Shenglan Li, Hua Zhang, Gehong Dong, Shoubo Yang, Xun Kang, Zhuang Kang, Chunlei Han, Shuo Yin, Wenbin Li
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Tumor Niche Network-Defined Subtypes Predict Immunotherapy Response of Esophageal Squamous Cell Cancer iScience (IF 5.8) Pub Date : 2024-04-22 Kyung-Pil Ko, Shengzhe Zhang, Yuanjian Huang, Bongjun Kim, Gengyi Zou, Sohee Jun, Jie Zhang, Yahui Zhao, Cecilia Martin, Karen J. Dunbar, Gizem Efe, Anil K. Rustgi, Hiroshi Nakagawa, Haiyang Zhang, Zhihua Liu, Jae-Il Park
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SIN-3 transcriptional coregulator maintains mitochondrial homeostasis and polyamine flux iScience (IF 5.8) Pub Date : 2024-04-22 Giovannetti Marina, Rodríguez-Palero María-Jesús, Fabrizio Paola, Nicolle Ophélie, Bedet Cécile, Michaux Grégoire, Witting Michael, Artal-Sanz Marta, Palladino Francesca
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Correlation between intestinal flora and GLP-1 receptor agonists dulaglutide in type 2 diabetes mellitus treatment—A preliminary longitudinal study iScience (IF 5.8) Pub Date : 2024-04-22 Lei Liang, XiaoYun Su, Yaxin Guan, Bin Wu, Xuxiang Zhang, Xin Nian
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A cingulate-hippocampal circuit mediates early depressive-like behavior in the mouse model of Alzheimer’s disease iScience (IF 5.8) Pub Date : 2024-04-19 Yanbing Chen, Huimin Peng, Kai Zhuang, Wenting Xie, Chenli Li, Meiqin Chen, Jin Xue, Xiaoting Huang, Tingting Zou, Hao Sun, Aiyu Lei, Ya Wang, Dan Can, Huifang Li, Tifei Yuan, Jie Zhang
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Vesicle Fusion and Release in Neurons under Dynamic Mechanical Equilibrium iScience (IF 5.8) Pub Date : 2024-04-19 Wenhao Liu, Tianyu Gao, Na Li, Shuai Shao, Bo Liu
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Postmortem metabolomics as a high-throughput cause-of-death screening tool for human death investigations iScience (IF 5.8) Pub Date : 2024-04-19 Liam J. Ward, Sara Kling, Gustav Engvall, Carl Söderberg, Fredrik C. Kugelberg, Henrik Green, Albert Elmsjö
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Nucleus-forming jumbophage PhiKZ therapeutically outcompetes non-nucleus-forming jumbophage Callisto iScience (IF 5.8) Pub Date : 2024-04-18 Ampapan Naknaen, Thanadon Samernate, Panida Saeju, Poochit Nonejuie, Vorrapon Chaikeeratisak
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The different impact of drug-resistant Leishmania on the transcription programs activated in neutrophils iScience (IF 5.8) Pub Date : 2024-04-18 Míriam Díaz-Varela, Andrea Sanchez-Hidalgo, Sandra Calderon-Copete, Virginie Tacchini, Tobias Shipley, Lady G. Ramírez, Julien Marquis, Olga L. Fernández, Nancy Gore Saravia, Fabienne Tacchini-Cottier
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A statistical approach for identifying single nucleotide variants that affect transcription factor binding iScience (IF 5.8) Pub Date : 2024-04-18 Nina Baumgarten, Laura Rumpf, Thorsten Kessler, Marcel H. Schulz
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Optogenetic Behavioral Studies in Depression Research: A Systematic Review, iScience (IF 5.8) Pub Date : 2024-04-18 Anika Spreen, Dana Alkhoury, Henrik Walter, Sabine Müller
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ER-stress in mouse serotonin neurons triggers a depressive phenotype alleviated by ketamine targeting eIF2α signaling iScience (IF 5.8) Pub Date : 2024-04-18 Lluis Miquel-Rio, Unai Sarriés-Serrano, María Sancho-Alonso, Eva Florensa-Zanuy, Verónica Paz, Esther Ruiz-Bronchal, Sharon Manashirov, Leticia Campa, Fuencisla Pilar-Cuéllar, Analia Bortolozzi
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Immunometabolic adaptation in monocytes underpins functional changes during pregnancy. iScience (IF 5.8) Pub Date : 2024-04-18
Abstract not available
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STPoseNet: A real-time spatiotemporal network model for robust mouse pose estimation iScience (IF 5.8) Pub Date : 2024-04-18 Songyan Lv, Jincheng Wang, Xiaowei Chen, Xiang Liao
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Phospholipase PLA2G7 is complementary to GPX4 in mitigating punicic acid induced ferroptosis in prostate cancer cells iScience (IF 5.8) Pub Date : 2024-04-18 Perrine Vermonden, Manon Martin, Katarzyna Glowacka, Ineke Neefs, Josef Ecker, Marcus Höring, Gerhard Liebisch, Cathy Debier, Olivier Feron, Yvan Larondelle
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String Quartet No. 1 “Polar Energy Budget” – Music composition using Earth observation data of polar regions iScience (IF 5.8) Pub Date : 2024-04-18 Hiroto Nagai
In recent years, advancements in digital processing have facilitated the transformation of data into sound, a process referred to as sonification. To raise awareness and understanding of climate change, various sonification endeavors utilizing Earth science data have surfaced; nevertheless, the outcomes frequently deviate from conventional music compositions. This backstory aims to examine the possibilities
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Human CD4+ Memory Phenotype T cells use mitochondrial metabolism to generate sensitive IFN-γ responses iScience (IF 5.8) Pub Date : 2024-04-18 Nikhila S. Bharadwaj, Nicholas A. Zumwalde, Arvinder Kapur, Manish Patankar, Jenny E. Gumperz
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Therapeutic application of adipose-derived stromal vascular fraction in myocardial infarction iScience (IF 5.8) Pub Date : 2024-04-18 Ilgiz Gareev, Ozal Beylerli, Tatiana Ilyasova, Aamir Ahmad, Huaizhang Shi, Vladimir Chekhonin
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Ovulation provides excessive coagulation and HGF signals to cause postoperative intraabdominal adhesions iScience (IF 5.8) Pub Date : 2024-04-18 Vaishnavi Seenan, Che-Fang Hsu, Kanchana Subramani, Pao-Chu Chen, Dah-Ching Ding, Tang-Yuan Chu
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Aurora-A condensation mediated by BuGZ aids its mitotic centrosome functions iScience (IF 5.8) Pub Date : 2024-04-18 Hui Zheng, Qiaoqiao Zhang, Xing Liu, Fan Shi, Fengrui Yang, Shengqi Xiang, Hao Jiang
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Glutamine promotes human CD8+ T cells and counteracts imiquimod-induced T cell hypo-responsiveness iScience (IF 5.8) Pub Date : 2024-04-18 Luisa Bopp, Maria Lopéz Martinez, Clara Schumacher, Robert Seitz, Manuel Huerta Arana, Henning Klapproth, Dominika Lukas, Ju Hee Oh, Daniela Neumayer, Jan W. Lackmann, Stefan Mueller, Esther von Stebut, Bent Brachvogel, Susanne Brodesser, Ramon I. Klein Geltink, Mario Fabri
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Exploring Host-Commensal-Pathogen Dynamics in Cell Line and Organotypic Human Intestinal Epithelial Models iScience (IF 5.8) Pub Date : 2024-04-18 Nening M. Nanlohy, Nina Johannesson, Lucas Wijnands, Laura Arroyo, Jelle de Wit, Gerco den Hartog, Katja C. Wolthers, Adithya Sridhar, Susana Fuentes
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Deciphering the TET3 interactome in primary thymic developing T cells iScience (IF 5.8) Pub Date : 2024-04-18 Dimitris Theofilatos, Tricia Ho, Greg Waitt, Tarmo Äijö, Lucio M. Schiapparelli, Erik J. Soderblom, Ageliki Tsagaratou
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Antimicrobial peptide LL37 and regulatory T-cell associated with late-onset sepsis in very preterm infants iScience (IF 5.8) Pub Date : 2024-04-18 Ren Zhuxiao, Yang Shuo, Han Jiangxue, Pei Jingjun, Zhang Qi, Wang Zhu, Xu Fang, Yang Jie
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VitTCR: A deep learning method for peptide recognition prediction iScience (IF 5.8) Pub Date : 2024-04-18 Mengnan Jiang, Zilan Yu, Xun Lan
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New AAV9 engineered variants with enhanced neurotropism and reduced liver off-targeting in mice and marmosets iScience (IF 5.8) Pub Date : 2024-04-18 Serena Gea Giannelli, Mirko Luoni, Angelo Iannielli, Jinte Middeldorp, Ingrid Philippens, Simone Bido, Jakob Körbelin, Vania Broccoli
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Sarcoma_CellminerCDB: A tool to interrogate the genomic and functional characteristics of a comprehensive collection of sarcoma cell lines iScience (IF 5.8) Pub Date : 2024-04-18 Camille Tlemsani, Christine M. Heske, Fathi Elloumi, Lorinc Pongor, Prashant Khandagale, Sudhir Varma, Paul S. Meltzer, Javed Khan, William C. Reinhold, Yves Pommier
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The IL-6 signaling pathway contributes critically to the immunomodulatory mechanism of human Decidua-derived mesenchymal stromal cells iScience (IF 5.8) Pub Date : 2024-04-18 Hyemin Na, Keon-Il Im, Nayoun Kim, Junseok Lee, Sojin Gil, Gi-June Min, Seok-Goo Cho
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MicroRNA-142-3p alleviated high salt-induced cardiac fibrosis via downregulating optineurin-mediated mitophagy iScience (IF 5.8) Pub Date : 2024-04-17 Yong Li, Kun Zhao, Yifang Hu, Fengze Yang, Peng Li, Yun Liu
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Mpox-AISM: AI-Mediated Super Monitoring for Mpox and Like-Mpox iScience (IF 5.8) Pub Date : 2024-04-17 Yubiao Yue, Minghua Jiang, Xinyue Zhang, Jialong Xu, Huacong Ye, Fan zhang, Zhenzhang Li, Yang Li
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Fitness or Socializing?A Multi-Dimensional Analysis of Online Fitness Communities Users iScience (IF 5.8) Pub Date : 2024-04-17 Wang Lei, Feng Wanxuan, Zhang Jianghua, Li Tuojian
The digital and social network revolution in the fitness industry will provide consumers with opportunities to achieve their healthy and active lifestyle goals both online and offline. The Online Fitness Communities provides us an ideal context for the health behaviour research with behavioural logs and user-generated content. Enhanced user profiles can empower platform operators to implement more
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Overexpression of Let-7a Mitigates Diploidization in Mouse Androgenetic Haploid Embryonic Stem Cells iScience (IF 5.8) Pub Date : 2024-04-17 Wenteng He, Hongming Tang, Yuanyuan Li, Mingzhu Wang, Yuanyuan Li, Jiayu Chen, Shaorong Gao, Zhiming Han
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Genetic distribution, characterization, and function of Escherichia coli type III secretion system 2 (ETT2) iScience (IF 5.8) Pub Date : 2024-04-18 Xinyu Wang, Hong Zhu, Jiangang Hu, Beibei Zhang, Weiqi Guo, Zhiyang Wang, Di Wang, Jingjing Qi, Mingxing Tian, Yanqing Bao, Fusheng Si, Shaohui Wang
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Molecular clues unveiling spinocerebellar ataxia type-12 pathogenesis iScience (IF 5.8) Pub Date : 2024-04-18 Manish Kumar, Shweta Sahni, Vivekanand A, Deepak Kumar, Neetu Kushwah, Divya Goel, Himanshi Kapoor, Achal K. Srivastava, Mohammed Faruq
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OlCHR, encoding a chromatin remodeling factor, is a killer causing hybrid sterility between rice species Oryza sativa and O. longistaminata iScience (IF 5.8) Pub Date : 2024-04-17 Zin Mar Myint, Yohei Koide, Wakana Takanishi, Tomohito Ikegaya, Choi Kwan, Kiwamu Hikichi, Yoshiki Tokuyama, Shuhei Okada, Kazumitsu Onishi, Ryo Ishikawa, Daisuke Fujita, Yoshiyuki Yamagata, Hideo Matsumura, Yuji Kishima, Akira Kanazawa
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Revealing neural dynamical structure of C. elegans with deep learning iScience (IF 5.8) Pub Date : 2024-04-17 Ruisong Zhou, Yuguo Yu, Chunhe Li
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Toward autonomous vehicles: A survey on cooperative vehicle-infrastructure system iScience (IF 5.8) Pub Date : 2024-04-17 Yangjie Ji, Zewei Zhou, Ziru Yang, Yanjun Huang, Yuanjian Zhang, Wanting Zhang, Lu Xiong, Zhuoping Yu
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Intracellularity, extracellularity, and squeezing in the symbiotic organ underpin nurturing and functioning of bacterial symbiont in leaf beetles iScience (IF 5.8) Pub Date : 2024-04-16 Kohei Oguchi, Toshiyuki Harumoto, Tatsuya Katsuno, Yu Matsuura, Soma Chiyoda, Takema Fukatsu
Cassidine leaf beetles are associated with genome-reduced symbiotic bacteria involved in pectin digestion. cells appear to be harbored in paired symbiotic organs located at the foregut-midgut junction either intracellularly or extracellularly, whereas the symbiont is extracellular in the ovary-accessory glands of adult females and during caplet transmission in eggs. However, using fluorescence and
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Network-based approach elucidates critical genes in BRCA subtypes and chemotherapy response in Triple Negative Breast Cancer iScience (IF 5.8) Pub Date : 2024-04-16 Piyush Agrawal, Navami Jain, Vishaka Gopalan, Annan Timon, Arashdeep Singh, Padma S. Rajagopal, Sridhar Hannenhalli
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Learning interpretable causal networks from very large datasets, application to 400,000 medical records of breast cancer patients iScience (IF 5.8) Pub Date : 2024-04-16 Marcel da Câmara Ribeiro-Dantas, Honghao Li, Vincent Cabeli, Louise Dupuis, Franck Simon, Liza Hettal, Anne-Sophie Hamy, Hervé Isambert
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SR9009 attenuates inflammation-related NPMSC pyroptosis and IVDD through NR1D1/NLRP3/IL-1β pathway iScience (IF 5.8) Pub Date : 2024-04-16 Ze-Nan Huang, Jing Wang, Ze-yu Wang, Ling-yuan Min, Hai-Ling Ni, Yan-Ling Han, You-yue Tian, Ya-Zhou Cui, Jing-Xiang Han, Xiao-Fei Cheng
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AKAP8 promotes ovarian cancer progression and antagonizes PARP inhibitor sensitivity through regulating hnRNPUL1 transcription iScience (IF 5.8) Pub Date : 2024-04-16 Youchaou Mobet, Haocheng Wang, Qinglv Wei, Xiaoyi Liu, Dan Yang, Hongyan Zhao, Yu Yang, Rosalie Anne Ngono Ngane, Jacob Souopgui, Jing Xu, Tao Liu, Ping Yi
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M-O-M mediated denaturation resistant P2 tetramer on the infected erythrocyte surface of malaria parasite imports serum fatty acids iScience (IF 5.8) Pub Date : 2024-04-16 Sudipta Das, Anwesa Manna, Oindrila Majumdar, Lena Dhara
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Migration of human T cells can be differentially directed by electric fields depending on the extracellular microenvironment iScience (IF 5.8) Pub Date : 2024-04-16 Karen Ende, Fabião Santos, Judith Guasch, Ralf Kemkemer
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STAT3 drives the expression of ACSL4 in acute kidney injury iScience (IF 5.8) Pub Date : 2024-04-16 Virginie Poindessous, Helene Lazareth, Gilles Crambert, Lydie Cheval, Julio L. Sampaio, Nicolas Pallet
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Contrasting consequences of podocyte insulin-like growth factor I receptor inhibition iScience (IF 5.8) Pub Date : 2024-04-16 Jennifer A. Hurcombe, Fern Barrington, Micol Marchetti, Virginie M.S. Betin, Emily E. Bowen, Abigail C. Lay, Lan Ni, Lusyan Dayalan, Robert J.P. Pope, Paul T. Brinkkoetter, Martin Holzenberger, Gavin I. Welsh, Richard J.M. Coward
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Parvalbumin interneuron activity in autism underlies susceptibility to PTSD-like memory formation iScience (IF 5.8) Pub Date : 2024-04-16 Alice Shaam Al Abed, Tiarne Vickie Allen, Noorya Yasmin Ahmed, Azza Sellami, Yovina Sontani, Elise Caitlin Rawlinson, Aline Marighetto, Aline Desmedt, Nathalie Dehorter
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Wybutosine hypomodification of tRNAphe activates HERVK and impairs neuronal differentiation iScience (IF 5.8) Pub Date : 2024-04-16 Chuanbo Sun, Ruirui Guo, Xiangyan Ye, Shiyi Tang, Manqi Chen, Pei Zhou, Miaomiao Yang, Caihua Liao, Hong Li, Bing Lin, Congwen Zang, Yifei Qi, Dingding Han, Yi Sun, Na Li, Dengna Zhu, Kaishou Xu, Hao Hu
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Co-Cu nanoparticles uniformly embedded in the intra-crystalline mesoporous Silicalite-1 for catalytic ammonia borane hydrolysis iScience (IF 5.8) Pub Date : 2024-04-15 Huijuan Wei, Yanan Cui, Huinan Hou, Xiaoguang Zheng, Peng Jin, Yiqiang Wen, Xiangyu Wang, Yanyan Liu, Baojun Li