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Near‐Infrared Fluorescent Ag2Se–Cetuximab Nanoprobes for Targeted Imaging and Therapy of Cancer
Small ( IF 13.3 ) Pub Date : 2016-11-07 , DOI: 10.1002/smll.201602309
Chun-Nan Zhu 1 , Gang Chen 2 , Zhi-Quan Tian 1 , Wei Wang 2 , Wen-Qun Zhong 2 , Zheng Li 1 , Zhi-Ling Zhang 1 , Dai-Wen Pang 1
Affiliation  

Theranostic nanoprobes integrated with diagnostic imaging and therapy capabilities have shown great potential for highly effective tumor therapy by realizing imaging‐guided drug delivery and tumor treatment. Developing novel high‐performance nanoprobes is an important basis for tumor theranostic application. Here, near‐infrared (NIR) fluorescent and low‐biotoxicity Ag2Se quantum dots (QDs) have been coupled with cetuximab, a clinical antiepidermal growth factor receptor antibody drug for tumor therapy, via a facile bioconjugation strategy to prepare multifunctional Ag2Se–cetuximab nanoprobes. Compared with the Ag2Se QDs alone, the Ag2Se–cetuximab nanoprobes display faster and more enrichment at the site of orthotopic tongue cancer, and thus present better NIR fluorescence contrast between the tumor and the surrounding regions. At 24 h postinjection, the NIR fluorescence of Ag2Se–cetuximab nanoprobes at the tumor site is still easily detectable, whereas no fluorescence is observed for the Ag2Se QDs. Moreover, the Ag2Se–cetuximab nanoprobes have also significantly inhibited the tumor growth and improved the survival rate of orthotopic tongue cancer‐bearing nude mice from 0% to 57.1%. Taken together, the constructed multifunctional Ag2Se–cetuximab nanoprobes have achieved combined targeted imaging and therapy of orthotopic tongue cancer, which may greatly contribute to the development of nanotheranostics.

中文翻译:

近红外荧光Ag2Se–西妥昔单抗纳米探针用于癌症的靶向成像和治疗

结合诊断成像和治疗功能的治疗诊断纳米探针通过实现成像指导的药物递送和肿瘤治疗,显示出了用于高效肿瘤治疗的巨大潜力。开发新型高性能纳米探针是肿瘤治疗学应用的重要基础。在这里,近红外(NIR)荧光和低生物毒性的Ag 2 Se量子点(QD)已与西妥昔单抗(一种用于肿瘤治疗的临床抗表皮生长因子受体抗体药物)通过一种简便的生物结合策略制备多功能的Ag 2 Se –cetuximab纳米探针。与单独的Ag 2 Se量子点相比,Ag 2Se-cetuximab纳米探针在原位舌癌部位显示更快,更富集,因此在肿瘤与周围区域之间呈现出更好的NIR荧光对比。注射后24 h,仍易于检测到肿瘤部位的Ag 2 Se–cetuximab纳米探针的NIR荧光,而未观察到Ag 2 Se QD的荧光。此外,Ag 2 Se–cetuximab纳米探针还显着抑制了肿瘤的生长,并将原位带有舌癌的裸鼠的存活率从0%提高到57.1%。总而言之,构建的多功能Ag 2塞妥昔单抗纳米探针已经实现了原位舌癌的联合靶向成像和治疗,这可能极大地促进了纳米治疗的发展。
更新日期:2016-11-07
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