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Mind the gap
Structure ( IF 5.7 ) Pub Date : 2023-06-01 , DOI: 10.1016/j.str.2023.05.005
Sven Larsen-Ledet 1 , Amelie Stein 1
Affiliation  

Amino acid deletions are high-risk, high-reward mutations, yet structural consequences are poorly understood. In this issue of Structure, Woods et al. (2023) individually deleted 65 residues from a small α-helical protein, structurally assayed the 17 soluble variants, and developed a computational model of deletion solubility combining Rosetta and AlphaFold2.



中文翻译:

注意间隔

氨基酸缺失是高风险、高回报的突变,但人们对结构后果知之甚少。在本期结构中,Woods 等人。(2023) 从一个小的 α 螺旋蛋白中单独删除 65 个残基,对 17 个可溶性变体进行结构分析,并开发了一个结合 Rosetta 和 AlphaFold2 的缺失溶解度计算模型。

更新日期:2023-06-02
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