当前位置: X-MOL 学术Hortic. Res. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
The gap-free genome of mulberry elucidates the architecture and evolution of polycentric chromosomes
Horticulture Research ( IF 8.7 ) Pub Date : 2023-05-31 , DOI: 10.1093/hr/uhad111
Bi Ma 1 , Honghong Wang 1 , Jingchun Liu 1 , Lin Chen 1 , Xiaoyu Xia 1 , Wuqi Wei 1 , Zhen Yang 1 , Jianglian Yuan 1 , Yiwei Luo 1 , Ningjia He 1
Affiliation  

Mulberry is a fundamental component of the global sericulture industry, and its positive impact on our health and the environment cannot be overstated. However, the mulberry reference genomes reported previously remained unassembled or unplaced sequences. Here, we report the assembly and analysis of the telomere-to-telomere gap-free reference genome of the mulberry species, Morus notabilis, which has emerged as an important reference in mulberry gene function research and genetic improvement. The mulberry gap-free reference genome produced here provides an unprecedented opportunity for us to study the structure and function of centromeres. Our results revealed that all mulberry centromeric regions share conserved centromeric satellite repeats with different copies. Strikingly, we found that M. notabilis is a species with polycentric chromosomes and the only reported polycentric chromosome species up to now. We propose a compelling model that explains the formation mechanism of new centromeres and addresses the unsolved scientific question of the chromosome fusion-fission cycle in mulberry species. Our study sheds light on the functional genomics, chromosome evolution, and genetic improvement of mulberry species.

中文翻译:

桑树的无间隙基因组阐明了多中心染色体的结构和进化

桑葚是全球养蚕业的基本组成部分,其对我们的健康和环境的积极影响不容小觑。然而,之前报道的桑树参考基因组仍然是未组装或未放置的序列。在这里,我们报告了桑树桑树端粒到端粒无间隙参考基因组的组装和分析,该基因组已成为桑树基因功能研究和遗传改良的重要参考。这里产生的桑树无间隙参考基因组为我们研究着丝粒的结构和功能提供了前所未有的机会。我们的结果表明,所有桑树着丝粒区域都共享具有不同拷贝的保守着丝粒卫星重复序列。引人注目的是,我们发现M. notabilis是一个具有多中心染色体的物种,也是迄今为止唯一报道的多中心染色体物种。我们提出了一个令人信服的模型,它解释了新着丝粒的形成机制,并解决了桑树物种中染色体融合裂变循环的未解决的科学问题。我们的研究揭示了桑树物种的功能基因组学、染色体进化和遗传改良。
更新日期:2023-05-31
down
wechat
bug