Although great achievements have been made in the study of artificial enzymes, the design of nanozymes with high catalytic activities of natural enzymes and the further establishment of sensitive biosensors still remain challenging. Here, two nanozymes, i.e., ZnCoFe three-atom nanozyme (TAzyme) and Sn single-atom nanozyme (SAzyme)/Ti₃C₂T_x, are developed, which show peroxidase-like catalytic activities by catalyzing the reaction of hydrogen peroxide (H₂O₂), 4-aminoantipyrine (4-AAP), and phenolic acids to generate colorimetric reactions. The involvement of different phenolic acids leads to the generation of different color products. These subtle color-variation profiles between these phenolic acids prompt us to exploit an electronic tongue based on the two nanozymes to distinguish phenolic acids. Data interpretation by the pattern recognition method, such as linear discriminant analysis (LDA), displays good clustering separation of six different phenolic acids at concentrations of 0.1 μM to 1 mM, validating the effectiveness of the colorimetric nanozyme sensor array.

中文翻译：

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基于两种单原子纳米酶的用于区分酚酸的视觉传感器阵列

尽管人工酶的研究取得了很大的成就，但设计具有天然酶高催化活性的纳米酶以及进一步建立灵敏的生物传感器仍然具有挑战性。在这里，开发了两种纳米酶，即 ZnCoFe 三原子纳米酶 (TAzyme) 和 Sn 单原子纳米酶 (SAzyme)/Ti ₃ C ₂ T _x，它们通过催化过氧化氢的反应显示出类过氧化物酶的催化活性 ( H ₂ O ₂)、4-氨基安替比林 (4-AAP) 和酚酸以产生比色反应。不同酚酸的参与导致不同颜色产物的产生。这些酚酸之间这些细微的颜色变化特征促使我们利用基于这两种纳米酶的电子舌头来区分酚酸。通过模式识别方法（如线性判别分析 (LDA)）进行的数据解释显示，浓度为 0.1 μM 至 1 mM 的六种不同酚酸具有良好的聚类分离，验证了比色纳米酶传感器阵列的有效性。