In recent years, magnetic nanoparticle sensor technologies have attracted considerable interest in the point-of-care-testing (POCT) field, especially in lateral flow immunoassays (LFIAs). Although the visual signal of magnetic nanoparticles is reduced during an inspection, it can be compensated for by magnetic induction, and detection results can be quantified by magnetic sensors. Sensors that use magnetic nanoparticles (MNPs) as markers can overcome the high background noise of complex samples. In this study, MNP signal detection strategies are described from the perspectives of magnetoresistance, magnetic flux, frequency mixing technology, and magnetic permeability, and the principles and development of each technology are introduced in detail. Typical applications of magnetic nanoparticle sensor technologies are introduced. By describing the advantages and limitations of different sensing strategies, we highlight the development and improvement directions of different sensing strategies. In general, the future development of magnetic nanoparticle sensor technologies will be toward intelligent, convenient, and mobile high-performance detection equipment.

中文翻译：

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磁性纳米探针侧流分析：最新进展

近年来，磁性纳米粒子传感器技术在即时检测（POCT）领域引起了极大的兴趣，特别是在侧流免疫测定（LFIA）领域。虽然磁性纳米颗粒的视觉信号在检查过程中有所减弱，但可以通过磁感应进行补偿，并且可以通过磁传感器对检测结果进行量化。使用磁性纳米粒子 (MNP) 作为标记的传感器可以克服复杂样品的高背景噪声。本研究从磁阻、磁通量、混频技术、磁导率等角度描述了MNP信号检测策略，并详细介绍了各项技术的原理和发展。介绍了磁性纳米颗粒传感器技术的典型应用。通过描述不同传感策略的优点和局限性，我们突出了不同传感策略的发展和改进方向。总体而言，磁性纳米颗粒传感器技术的未来发展将朝着智能化、便捷化、移动化的高性能检测设备方向发展。