Enzymes have many highly desirable properties as catalysts, but adapting them to non-natural reactions or conditions requires re-design and optimization. One approach is directed evolution, which does not require prior knowledge of the structure or enzyme dynamics but takes many rounds to generate catalysts with the desired attributes or reactivity. Continuous evolution of enzymes in a high-throughput, yet rapid, manner is desirable. Now, Rosenthal et al. have developed a microfluidic method that relies on direct measurement of enzymatic activity for integrated screening and sorting.

中文翻译：

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加速酶的进化

酶作为催化剂具有许多非常理想的特性，但要使它们适应非自然反应或条件需要重新设计和优化。一种方法是定向进化，它不需要结构或酶动力学的先验知识，但需要很多轮才能生成具有所需属性或反应性的催化剂。酶以高通量但快速的方式持续进化是可取的。现在，罗森塔尔等人。已经开发出一种微流体方法，该方法依赖于直接测量酶活性以进行综合筛选和分类。