The core promoter determines not only where gene transcription initiates but also the transcriptional activity in both basal and enhancer-induced conditions. Multiple short sequence elements within the core promoter have been identified in different species, but how they function together and to what extent they are truly species-specific has remained unclear. In this issue of Genes & Development, Vo ngoc and colleagues (pp. 377–382) report undertaking massively parallel measurements of synthetic core promoters to generate a large data set of their activities that informs a statistical learning model to identify the sequence differences of human and Drosophila core promoters. This machine learning model was then applied to design gene core promoters that are particularly specific for the human transcriptional machinery.

中文翻译：

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人工智能的设计师基因

核心启动子不仅决定基因转录的起始位置，还决定基础和增强子诱导条件下的转录活性。已在不同物种中鉴定出核心启动子内的多个短序列元件，但它们如何一起发挥作用以及它们在多大程度上真正具有物种特异性仍不清楚。在本期《基因与发展》中，Vo ngoc 及其同事（第 377-382 页）报告称，他们对合成核心启动子进行了大规模并行测量，以生成其活动的大型数据集，为统计学习模型提供信息，以识别人类基因的序列差异。和果蝇核心推动者。然后将该机器学习模型应用于设计特别针对人类转录机制的基因核心启动子。