Herein, we report the highly enantioselective α-fluorination of both cyclic and acyclic β-dicarbonyl compounds, including β-diketones, β-ketoesters, and β-ketoamides. The reactions with β,β-diaryl serines as primary amine organocatalysts were enhanced by adding alkali carbonates, such as Na₂CO₃ or Li₂CO₃, and enabled the reaction to be conducted with only 1.1 equiv of Selectfluor. The optimal conditions afforded the α-fluorinated β-dicarbonyl compounds in 50–99% yield with excellent enantioselectivity (up to 98% ee).

中文翻译：

---

碱金属碳酸盐改善 β-二羰基化合物的 β,β-二芳基丝氨酸催化的对映选择性 α-氟化反应

在此，我们报道了环状和无环β-二羰基化合物（包括β-二酮、β-酮酯和β-酮酰胺）的高度对映选择性α-氟化。通过添加碱金属碳酸盐，例如Na ₂ CO ₃或Li ₂ CO ₃ ，可以增强以β,β-二芳基丝氨酸作为伯胺有机催化剂的反应，并且使得反应能够仅用1.1当量的Selectflu进行。最佳条件提供了 α-氟化 β-二羰基化合物，产率为 50-99%，具有优异的对映选择性（高达 98% ee）。