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Formation of Amorphous Iron-Calcium Phosphate with High Stability
Advanced Materials ( IF 29.4 ) Pub Date : 2023-05-25 , DOI: 10.1002/adma.202301422 Song Chen 1 , Dachuan Liu 1 , Le Fu 2 , Bing Ni 3 , Zongkun Chen 3 , Jennifer Knaus 3 , Elena V Sturm 3, 4 , Bohan Wang 2 , Håvard Jostein Haugen 5 , Hongji Yan 6, 7, 8 , Helmut Cölfen 3 , Bin Li 1, 9, 10
Advanced Materials ( IF 29.4 ) Pub Date : 2023-05-25 , DOI: 10.1002/adma.202301422 Song Chen 1 , Dachuan Liu 1 , Le Fu 2 , Bing Ni 3 , Zongkun Chen 3 , Jennifer Knaus 3 , Elena V Sturm 3, 4 , Bohan Wang 2 , Håvard Jostein Haugen 5 , Hongji Yan 6, 7, 8 , Helmut Cölfen 3 , Bin Li 1, 9, 10
Affiliation
Amorphous iron-calcium phosphate (Fe-ACP) plays a vital role in the mechanical properties of teeth of some rodents, which are very hard, but its formation process and synthetic route remain unknown. Here, the synthesis and characterization of an iron-bearing amorphous calcium phosphate in the presence of ammonium iron citrate (AIC) are reported. The iron is distributed homogeneously on the nanometer scale in the resulting particles. The prepared Fe-ACP particles can be highly stable in aqueous media, including water, simulated body fluid, and acetate buffer solution (pH 4). In vitro study demonstrates that these particles have good biocompatibility and osteogenic properties. Subsequently, Spark Plasma Sintering (SPS) is utilized to consolidate the initial Fe-ACP powders. The results show that the hardness of the ceramics increases with the increase of iron content, but an excess of iron leads to a rapid decline in hardness. Calcium iron phosphate ceramics with a hardness of 4 GPa can be achieved, which is higher than that of human enamel. Furthermore, the ceramics composed of iron-calcium phosphates show enhanced acid resistance. This study provides a novel route to prepare Fe-ACP, and presents the potential role of Fe-ACP in biomineralization and as starting material to fabricate acid-resistant high-performance bioceramics.
中文翻译:
高稳定性非晶态磷酸铁钙的形成
无定形磷酸铁钙(Fe-ACP)对某些啮齿类动物牙齿的机械性能起着至关重要的作用,牙齿非常坚硬,但其形成过程和合成路线仍不清楚。本文报道了在柠檬酸铁铵 (AIC) 存在下含铁无定形磷酸钙的合成和表征。铁在所得颗粒中以纳米级均匀分布。制备的Fe-ACP颗粒在水、模拟体液和醋酸盐缓冲溶液(pH 4)等水介质中高度稳定。体外研究表明这些颗粒具有良好的生物相容性和成骨特性。随后,利用火花等离子烧结 (SPS) 来固结初始 Fe-ACP 粉末。结果表明,陶瓷的硬度随着铁含量的增加而增加,但铁过量会导致硬度迅速下降。磷酸铁钙陶瓷的硬度可以达到4GPa,比人体牙釉质的硬度还要高。此外,由磷酸铁钙组成的陶瓷表现出增强的耐酸性。这项研究提供了一种制备 Fe-ACP 的新途径,并展示了 Fe-ACP 在生物矿化中的潜在作用以及作为制造耐酸高性能生物陶瓷的起始材料。
更新日期:2023-05-25
中文翻译:
高稳定性非晶态磷酸铁钙的形成
无定形磷酸铁钙(Fe-ACP)对某些啮齿类动物牙齿的机械性能起着至关重要的作用,牙齿非常坚硬,但其形成过程和合成路线仍不清楚。本文报道了在柠檬酸铁铵 (AIC) 存在下含铁无定形磷酸钙的合成和表征。铁在所得颗粒中以纳米级均匀分布。制备的Fe-ACP颗粒在水、模拟体液和醋酸盐缓冲溶液(pH 4)等水介质中高度稳定。体外研究表明这些颗粒具有良好的生物相容性和成骨特性。随后,利用火花等离子烧结 (SPS) 来固结初始 Fe-ACP 粉末。结果表明,陶瓷的硬度随着铁含量的增加而增加,但铁过量会导致硬度迅速下降。磷酸铁钙陶瓷的硬度可以达到4GPa,比人体牙釉质的硬度还要高。此外,由磷酸铁钙组成的陶瓷表现出增强的耐酸性。这项研究提供了一种制备 Fe-ACP 的新途径,并展示了 Fe-ACP 在生物矿化中的潜在作用以及作为制造耐酸高性能生物陶瓷的起始材料。