Aim To investigate the effect of gender on the clinical features and outcomes of ocular toxoplasmosis. Methods 262 patients (139 women and 123 men) presenting to a tertiary referral uveitis service in Ribeirão Preto, Brazil, with serological and clinical evidence of ocular toxoplasmosis were prospectively enrolled in an observational study. Predefined data items including demographics, descriptors of uveitis and ocular toxoplasmosis, best-corrected visual acuity and ocular complications were disaggregated by gender and compared statistically. Results Approximately equal numbers of women and men had active versus inactive ocular toxoplasmosis. In both women and men, most infections were remotely acquired. Men were significantly more likely to present with primary active disease than women (24.4% vs 12.9%); conversely, women were significantly more likely to present with recurrent active disease than men (36.0% vs 28.5%). One toxoplasmic retinal lesion was observed in more eyes of men than eyes of women (50.4% vs 35.3%), while women’s eyes were more likely to have multiple lesions than men’s eyes (54.7% vs 39.8%). Lesions in women’s eyes were significantly more likely to occur at the posterior pole compared with those in men’s eyes (56.1% vs 39.8%). Measures of vision were similar for women and men. There were no significant differences in measures of visual acuity, ocular complications, and occurrence and timing of reactivations between the genders. Conclusion Ocular toxoplasmosis has equivalent outcomes in women and men, with clinical differences in the form and type of disease, as well as characteristics of the retinal lesion. All data relevant to the study are included in the article.

中文翻译：

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性别对眼弓形体病临床特征和结果的影响

目的 探讨性别对眼部弓形虫病临床特征和结局的影响。方法 262 名患者（139 名女性和 123 名男性）在巴西里贝朗普雷图就诊于三级转诊葡萄膜炎服务，具有眼部弓形虫病的血清学和临床证据，前瞻性地参加了一项观察性研究。预定义的数据项包括人口统计学、葡萄膜炎和眼弓形体病的描述符、最佳矫正视力和眼部并发症，按性别分类并进行统计比较。结果 患有活动性和非活动性眼弓形体病的女性和男性人数大致相等。在女性和男性中，大多数感染都是远程获得的。男性比女性更容易出现原发性活动性疾病（24.4% 对 12.9%）；反过来，女性比男性更容易出现复发性活动性疾病（36.0% 对 28.5%）。观察到一处弓形虫视网膜病变的男性多于女性（50.4% vs 35.3%），而女性的眼睛比男性的眼睛更容易出现多发病变（54.7% vs 39.8%）。与男性眼睛相比，女性眼睛的病变更容易发生在后极（56.1% 对 39.8%）。女性和男性的视力测量结果相似。两性之间在视力、眼部并发症以及重新激活的发生和时间方面没有显着差异。结论 眼部弓形虫病在女性和男性中的结局相当，但在疾病的形式和类型以及视网膜病变的特征方面存在临床差异。