Sulfoxides are ubiquitous in both naturally and synthetically bioactive molecules. We report herein a redox-neutral and mild approach for radical sulfinylation of redox-active esters via dual photoredox and copper catalysis, furnishing a series of functionalized sulfoxides. The reaction could accommodate a range of tertiary, secondary, and primary carboxylic acids, as well as exhibit wide functional group compatibility. The chemistry features a high degree of practicality, is scalable, and allows late-stage modification of bioactive pharmaceuticals.

中文翻译：

---

催化脱羧自由基亚磺酰化

亚砜在天然和合成生物活性分子中无处不在。我们在此报告了一种氧化还原中性和温和的方法，通过双重光氧化还原和铜催化对氧化还原活性酯进行自由基亚磺酰化，提供一系列功能化的亚砜。该反应可以适应一系列叔、仲和伯羧酸，并表现出广泛的官能团相容性。该化学具有高度实用性、可扩展性，并允许对生物活性药物进行后期修饰。