A new Pd(II)-catalyzed annulation/iododifluoromethylation of enynones has been developed for the synthesis of versatile 1-indanones with moderate to good yields (26 examples). The present strategy enabled the concomitant incorporation of two important difluoroalkyl and iodo functionalities into 1-indenone skeletons with (E)-stereoselectivity. The mechanistic pathway was proposed, consisting of the difluoroalkyl radical-triggered α,β-conjugated addition/5-exo-dig cyclization/metal radical cross-coupling/reductive elimination cascade.

中文翻译：

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催化自由基引发的烯炔环化/碘二氟甲基化用于立体定向合成 1-茚酮

一种新的 Pd(II) 催化烯炔环化/碘二氟甲基化方法已被开发出来，用于合成具有中等至良好产率的多功能 1-茚满酮（26 个实例）。本策略能够将两个重要的二氟烷基和碘官能团同时并入具有 ( E )-立体选择性的 1-茚酮骨架中。提出了由二氟烷基自由基触发的α,β-共轭加成/5- exo -dig环化/金属自由基交叉偶联/还原消除级联组成的机理途径。