Background and Purpose

The aim of this study was to evaluate the relationship between dietary total antioxidant capacity (DTAC) and atherosclerotic carotid stenosis in patients with ischemic stroke.

Methods

Patients with acute ischemic stroke were consecutively enrolled. Daily food consumption was estimated by a semi-quantitative food frequency questionnaire (FFQ). DTAC was calculated based on classified food intake. Antioxidant potential value was measured by ferric-reducing antioxidant power (FRAP) and oxygen radical absorbance capacity (ORAC) methods. Evaluation of carotid artery stenosis was based on computed tomography angiography (CTA). Logistic regression was used to assess the relationship between DTAC and degree of carotid stenosis.

Results

Of the 608 enrolled, 232 patients (38.2%) had moderate or severe carotid stenosis. After adjusting for major confounding factors, FRAP (OR =0.640; 95% CI: 0.410-0.998; P =0.049) and ORAC (OR =0.625; 95% CI: 0.400-0.976; P =0.039) were associated with lower degree of carotid artery stenosis (third vs first tertile). Spearman analysis indicated that FRAP (r =-0.121, P =0.003) and ORAC (r =-0.147, P <0.001) were correlated with degree of carotid stenosis.

Conclusions

DTAC may influence the initiation and development of atherosclerosis, and, therefore, the risk of ischemic stroke.

中文翻译：

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缺血性脑卒中患者膳食抗氧化能力与动脉粥样硬化性颈动脉狭窄的相关性

背景和目的

本研究的目的是评估缺血性卒中患者膳食总抗氧化能力 (DTAC) 与动脉粥样硬化性颈动脉狭窄之间的关系。

方法

急性缺血性卒中患者连续入组。通过半定量食物频率问卷 (FFQ) 估算每日食物消耗量。DTAC 是根据分类的食物摄入量计算的。通过铁还原抗氧化能力（FRAP）和氧自由基吸收能力（ORAC）方法测量抗氧化潜力值。颈动脉狭窄的评估基于计算机断层扫描血管造影术（CTA）。Logistic回归用于评估DTAC与颈动脉狭窄程度之间的关系。

结果

在登记的 608 名患者中，232 名患者 (38.2%) 患有中度或重度颈动脉狭窄。调整主要混杂因素后，FRAP（OR =0.640；95% CI：0.410-0.998；P =0.049）和 ORAC（OR =0.625；95% CI：0.400-0.976；P =0.039）与较低程度的颈动脉狭窄（第三与第一三分位数）。Spearman 分析表明，FRAP（r =-0.121，P =0.003）和 ORAC（r =-0.147，P <0.001）与颈动脉狭窄程度相关。

结论

DTAC 可能会影响动脉粥样硬化的发生和发展，从而影响缺血性中风的风险。