Zebrafish hearts can regenerate by replacing damaged tissue with new cardiomyocytes. Although the steps leading up to the proliferation of surviving cardiomyocytes have been extensively studied, little is known about the mechanisms that control proliferation and redifferentiation to a mature state. We found that the cardiac dyad, a structure that regulates calcium handling and excitation-contraction coupling, played a key role in the redifferentiation process. A component of the cardiac dyad called leucine-rich repeat–containing 10 (Lrrc10) acted as a negative regulator of proliferation, prevented cardiomegaly, and induced redifferentiation. We found that its function was conserved in mammalian cardiomyocytes. This study highlights the importance of the underlying mechanisms required for heart regeneration and their application to the generation of fully functional cardiomyocytes.

中文翻译：

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钙和肌节之间的相互作用指导再生过程中的心肌细胞成熟

斑马鱼的心脏可以通过用新的心肌细胞替换受损组织来再生。尽管导致存活心肌细胞增殖的步骤已被广泛研究，但对于控制增殖和再分化至成熟状态的机制知之甚少。我们发现心脏二联体是一种调节钙处理和兴奋-收缩偶联的结构，在再分化过程中发挥了关键作用。称为富含亮氨酸重复序列 10 (Lrrc10) 的心脏二元组的一个成分充当增殖的负调节因子，防止心脏肥大，并诱导再分化。我们发现它的功能在哺乳动物心肌细胞中是保守的。