In this work, the solubilities of naproxen and indomethacin in supercritical carbon dioxide (scCO₂) were investigated from both experimental and theoretical points of view. Experimentally, the solubilities of those active pharmaceutical ingredients (APIs) in scCO₂ and scCO₂/ethyl acetate were measured using a variable-volume high-pressure view cell at $\mathrm{T}=60\mathrm{℃}$ and pressures between 150 and 429 bar. Results showed two different trends for the solubility of naproxen in scCO₂ and further PXRD analysis revealed a change in naproxen crystal structure for pressures above 250 bar. Moreover, the influence of ethyl acetate on the solubility of indomethacin in scCO₂ was investigated. At constant pressure, solubility was observed to increase with increasing ethyl acetate concentration. PC-SAFT was used to describe the solubility of both APIs in scCO₂ and of indomethacin in the scCO₂/ethyl acetate mixture over the entire pressure range. The melting properties of different polymorphic forms were considered for the solubility calculations, and the model accurately described the investigated systems.

在这项工作中，萘普生和吲哚美辛在超临界二氧化碳 (scCO ₂ ) 中的溶解度从实验和理论的角度进行了研究。_{在实验上，这些活性药物成分 (API) 在 scCO 2}和 scCO ₂ /乙酸乙酯中的溶解度是在$\mathrm{吨}=60\mathrm{℃}$压力在 150 到 429 巴之间。_{结果显示萘普生在 scCO 2}中的溶解度有两种不同的趋势，进一步的 PXRD 分析揭示了压力高于 250 巴时萘普生晶体结构的变化。此外，研究了乙酸乙酯对吲哚美辛在scCO _{2中的溶解度的影响。}在恒定压力下，观察到溶解度随着乙酸乙酯浓度的增加而增加。PC-SAFT 用于描述在整个压力范围内两种 API 在 scCO ₂中的溶解度和吲哚美辛在 scCO _{2 /乙酸乙酯混合物中的溶解度。}溶解度计算考虑了不同多晶型物的熔化特性，模型准确地描述了所研究的系统。