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Comparison of Group-Level and Individualized Brain Regions for Measuring Change in Longitudinal Tau Positron Emission Tomography in Alzheimer Disease.
JAMA Neurology ( IF 29.0 ) Pub Date : 2023-05-08 , DOI: 10.1001/jamaneurol.2023.1067
Antoine Leuzy 1 , Alexa Pichet Binette 1 , Jacob W Vogel 2, 3 , Gregory Klein 4 , Edilio Borroni 4 , Matteo Tonietto 4 , Olof Strandberg 1 , Niklas Mattsson-Carlgren 1, 5, 6 , Sebastian Palmqvist 1, 7 , Michael J Pontecorvo 8, 9 , Leonardo Iaccarino 8, 9 , Erik Stomrud 1, 7 , Rik Ossenkoppele 1, 10, 11 , Ruben Smith 1, 5 , Oskar Hansson 1, 7 ,
Affiliation  

Longitudinal tau positron emission tomography (PET) is a relevant outcome in clinical trials evaluating disease-modifying therapies in Alzheimer disease (AD). A key unanswered question is whether the use of participant-specific (individualized) regions of interest (ROIs) is superior to conventional approaches where the same ROI (group-level) is used for each participant.

中文翻译:

用于测量阿尔茨海默病纵向 Tau 正电子发射断层扫描变化的组级和个体化脑区域的比较。

纵向 tau 正电子发射断层扫描 (PET) 是评估阿尔茨海默病 (AD) 疾病改善疗法的临床试验的相关结果。一个关键的悬而未决的问题是,使用参与者特定(个性化)的感兴趣区域(ROI)是否优于传统方法,在传统方法中,每个参与者使用相同的 ROI(组级)。
更新日期:2023-05-08
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