Tricyclic peptides have reduced conformational flexibility, making them well suited for ligand development. Researchers have now generated large combinatorial libraries of tricyclic peptides using a disulfide-directing motif. Screening these libraries discovered binders to challenging protein targets.

中文翻译：

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制作三轮车的图案

三环肽降低了构象灵活性，使其非常适合配体开发。研究人员现在已经使用二硫键导向基序生成了大型三环肽组合库。筛选这些文库发现了具有挑战性的蛋白质靶点的结合物。