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Nonmetabolic role for CKB in ferroptosis
Nature Cell Biology ( IF 21.3 ) Pub Date : 2023-05-08 , DOI: 10.1038/s41556-023-01104-0
Eikan Mishima 1 , Marcus Conrad 1
Affiliation  

The selenoprotein glutathione peroxidase 4 (GPX4) is the guardian of ferroptosis, a form of cell death earmarked by unrestrained lipid peroxidation. A new study shows that the metabolic enzyme creatinine kinase B (CKB) phosphorylates GPX4, which may influence the susceptibility of cancer cells to ferroptosis.

中文翻译:

CKB 在铁死亡中的非代谢作用

硒蛋白谷胱甘肽过氧化物酶 4 (GPX4) 是铁死亡的守护者,铁死亡是一种以不受限制的脂质过氧化为标志的细胞死亡形式。一项新的研究表明,代谢酶肌酐激酶 B (CKB) 磷酸化 GPX4,这可能会影响癌细胞对铁死亡的易感性。
更新日期:2023-05-09
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