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Base-Catalyzed Synthesis of Spiropyrazoloaminonitriles with Arylidene Pyrazolone and Vinylogous Malononitriles through a Cascade Michael Addition and Cyclization
European Journal of Organic Chemistry ( IF 2.8 ) Pub Date : 2023-05-07 , DOI: 10.1002/ejoc.202300357
Chaitanya Ittamalla 1 , Saikrishna Chintha 2 , Nagaraju Medishetti 3 , Jagadeesh Babu Nanubolu 4 , Krishnaiah Atmakur 5
Affiliation  

Synthesis of title compounds were accomplished by a reaction of vinyl malononitriles and arylidene pyrazolones catalyzed by base. This protocol proceeds via Michael addition followed by intramolecular cyclization leading to the formation of two new C−C bonds. Further the same reaction was also conducted with α,α-dicyano olefins and vinyl malononitriles to furnish 1,6-dihydro biphenyl compounds. Simple reaction conditions, high yields and compatibility are the advantages of this protocol.

中文翻译:

通过级联迈克尔加成和环化,碱催化合成螺吡唑氨基腈与亚芳基吡唑啉酮和乙烯系丙二腈

标题化合物的合成是通过乙烯基丙二腈和亚芳基吡唑啉酮在碱催化下的反应完成的。该协议通过Michael 添加进行,然后进行分子内环化,从而形成两个新的 C−C 键。进一步用α,α-二氰基烯烃和乙烯基丙二腈进行同样的反应得到1,6-二氢联苯化合物。反应条件简单、产率高、兼容性好是该方案的优点。
更新日期:2023-05-07
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