Even though cancer therapeutic methods are improving rapidly, cancer recurrence has always remained a big challenge. Even a small lesion of missed neoplastic cells during the surgery can result in tumor recurrence and the consequent silent metastasis, making this issue more critical and complicated for prognosis. Hence, developing new methods with capability of clearing margins without side effects to the healthy surrounding tissues has always been a significant concern. This study introduced a method to prevent cancer recurrence by exposing cavity side margins to irreversible electroporation (IRE) through a balloon catheter. For this purpose, the induced tumor in BALB/c mice (as in-vivo animal model) is mostly resected, and just a traceable part is left as a model of the involved margin. A balloon-catheter is then filled with the conductive saline and inserted into the postoperative cavity. The IRE is applied through a low-cost high-voltage triboelectric nanogenerator (TENG) that is connected to the balloon catheter. Delivering a homogenous IRE without any muscle contraction by the elastic spherical balloon ensures that all the margin surfaces are exposed to the electric field. Monitoring the size of the remained tumor by the sonography imaging reveals that just 15 days of TENG-based balloon catheter irreversible electroporation (TBC-IRE) reduces the size of remained tumor by 94%, while 303% growth is observed in the remained tumor of control group of mice. Further histological analysis of this treatment disclosed no remarkable side effects on the adjacent tissue or organ. Everything considered, margin therapy by TBC-IRE can be a promising method for preventing cancer recurrence and potentially improving cancer-bearing patients' survival.

尽管癌症治疗方法正在迅速改进，但癌症复发仍然是一个巨大的挑战。即使是在手术过程中遗漏了一个小的肿瘤细胞病灶，也会导致肿瘤复发和随之而来的无声转移，使得这个问题对于预后来说更加关键和复杂。因此，开发能够清除边缘而不对周围健康组织产生副作用的新方法一直是一个重要问题。本研究介绍了一种预防癌症复发的方法，该方法通过球囊导管将腔侧边缘暴露于不可逆电穿孔 (IRE)。为此，BALB/c小鼠（作为体内动物模型）的诱导肿瘤大部分被切除，只留下可追踪的部分作为受累边缘的模型。然后用导电盐水填充球囊导管并插入术后腔内。IRE 通过连接到球囊导管的低成本高压摩擦纳米发电机 (TENG) 应用。通过弹性球形气球在没有任何肌肉收缩的情况下提供均匀的 IRE，确保所有边缘表面都暴露在电场中。通过超声成像监测剩余肿瘤的大小显示，仅 15 天的基于 TENG 的球囊导管不可逆电穿孔 (TBC-IRE) 将剩余肿瘤的大小减少了 94%，而在剩余肿瘤中观察到 303% 的生长对照组小鼠。对该治疗的进一步组织学分析表明，对邻近组织或器官没有明显的副作用。综合考虑，