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Innate immune cell genetic risk factors are linked to COVID-19 severity
Nature Genetics ( IF 30.8 ) Pub Date : 2023-05-05 , DOI: 10.1038/s41588-023-01378-y
Nature Genetics ( IF 30.8 ) Pub Date : 2023-05-05 , DOI: 10.1038/s41588-023-01378-y
Single-cell RNA-sequencing analysis combined with host genetic data for a Japanese population reveals the dysfunction of innate immune cells, particularly non-classical monocytes, in individuals with severe COVID-19, as well as enrichment of host genetic risk factors for severe COVID-19 in monocytes and dendritic cells.
中文翻译:
先天免疫细胞遗传风险因素与 COVID-19 的严重程度有关
单细胞 RNA 测序分析与日本人群的宿主遗传数据相结合,揭示了重症 COVID-19 患者先天免疫细胞(尤其是非经典单核细胞)的功能障碍,以及重症 COVID 的宿主遗传风险因素的丰富-19 在单核细胞和树突状细胞中。
更新日期:2023-05-05
中文翻译:
先天免疫细胞遗传风险因素与 COVID-19 的严重程度有关
单细胞 RNA 测序分析与日本人群的宿主遗传数据相结合,揭示了重症 COVID-19 患者先天免疫细胞(尤其是非经典单核细胞)的功能障碍,以及重症 COVID 的宿主遗传风险因素的丰富-19 在单核细胞和树突状细胞中。